Diabetic patients who have an abnormal blood glucose level suffer from acute effects of hypoglycemia and long term effects of hyperglycemia which include disorders of eyes, kidneys and nerves. This paper introduces the concept of an artificial pancreas which is a revolutionary device for the diabetic population. The artificial pancreas (AP), known as closed-loop control of blood glucose in diab...

Possessing putative hypolipidemic effects, Teucrium polium (TP) have been traditionally used as a medicinal plant in Iran. The aim of the present study was to investigate this effect on the sucrose-induced insulin resistance male rat model. Thirty Wistar male rats weighting 180 ± 20 g were divided into five groups of six each. Four groups were given sucrose 50% in drinking water for 10 weeks. I...

In this study, the effects of late gestational undernutrition (LGU) on plasma concentration of insulin-like growth factor 1 (IGF-I), leptin, insulin and glucose in subsequent sucking lambs was investigated. Ten twin-bearing ewes were fed either restrictedly (Restricted) or adequately (Control) during the last six weeks of gestation and were fed ad libitum after parturition. Blood samples were t...

Seven volunteers aged 12.0 to 17.9 years participated in a trial to compare conventional insulin treatment with continuous open loop (pump) insulin infusion. After 6 weeks of conventional treatment followed by 6 weeks of insulin pump treatment, 4 children chose to manage their diabetes permanently by means of the insulin pump. The mean blood glucose concentration (based on home blood glucose mo...

Mathematical modeling of the glucose–insulin system forms core simulators in field glucose metabolism. The complexity human biological systems makes it a challenging task for physiological models to encompass entirety such systems. Even though modern diabetes perform respectable simulating action, they are unable estimate various phenomena affecting glycemic profile an individual as disturbance...

Hyperglycaemia in critically ill patients increases the risk of further complications and mortality. A long-term verification of a model that captures the essential glucoseand insulin-kinetics is presented, using retrospective data gathered in an Intensive Care Unit (ICU). The model uses only two patient specific parameters, for glucose clearance and insulin sensitivity. The optimization of the...

Mathematical modelling of glucose-insulin system is significantly important to understand the body regulation control, to analyze experimental data based on clinical trials, to identify and quantify relevant physiological parameters, to design proper clinical trials and to assess diabetes therapies. In general, critically ill patients with blood glucose concentrations between 10.0 to 12.2 mmol/...

conclusions an intraoperative dex infusion maintains blood glucose levels at a constant level relative to baseline in diabetic patients within 24 hours postoperatively. the frequency of hyperglycemia was low in group a in the perioperative period compared with that in the control group (group b). methods twenty diabetic patients were randomly allocated to two groups (n = 10). group a patients w...

It is well known that blood glucose is a major source of energy for cellular activities and the liver is an important organ for the storage of glucose in the form of glycogen. It is generally recognized that blood glucose level is maintained at a relatively constant level, and catecholamines (epinephrine and norepinephrine) released from the adrenal gland, and insulin and glucagon released from...