This study was designed to test the hypothesis that a reduced number of nephrons from birth leads to increased arterial pressure in adulthood. Newborn Sprague-Dawley rat pups were uninephrectomized during the first 24 h after birth. In chronically instrumented adult animals (∼22 wk), mean arterial pressure on a normal (0.20%)-Na+ diet was higher in uninephrectomized rats (133 ± 2 mmHg vs. 121 ±...

Limited prospective data are available on the importance of estimated glomerular filtration rate (GFR) and proteinuria in the prediction of all-cause mortality (ACM) in community-based elderly populations. We examined the relationship between GFR or proteinuria and ACM in 949 randomly selected community-dwelling elderly subjects (aged ≥65 years) over a 5-year period. A spot urine sample was use...

Reference 1. Assi LK, McIntyre N, Fraser S, Harris S, Hutchison CA, McIntyre CW, et al. (2015) The Association between Polyclonal Combined Serum Free Light Chain Concentration and Mortality in Individuals with Early Chronic Kidney Disease. PLoS ONE 10(7): e0129980. doi:10.1371/journal.pone.0129980 PMID: 26132658 Fig 4. Correlation of cFLC and eGFR. There was a significant inverse association wi...

• There is no convincing evidence that serum cystatin C measurement offers any clinical advantage over estimated glomerular filtration rate (eGFR) (Level III evidence, small-to-medium observational cohort studies, surrogate outcomes, weak effect) except that serum cystatin C appears to be superior to both serum creatinine and eGFR as a predictor of cardiovascular events in the eldely (age ≥ 65 ...

The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5 ± 8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome compone...

To determine the physiological basis for the low glomerular filtration rate in chronic malnutrition, micropuncture studies were performed in Munich-Wistar rats chronically pair-fed isocaloric diets of either low (group 1, nine rats) or high protein content (group 2, nine rats). Despite the absence of hypoalbuminemia, average values for single nephron and total kidney glomerular filtration rate ...