After nigrostriatal dopaminergic denervation, the output nuclei of the basal ganglia, the medial globus pallidus and substantia nigra pars reticulata (Snr), become overactive, in part, because of increased activity of excitatory afferents from the subthalamic nucleus (STN). Because STN uses glutamate as a transmitter, we examined whether there are regulatory changes in glutamate receptor bindin...

In this paper we describe our work in progress to integrate the Shibboleth SAMLbased framework and Globus Toolkit’s PKIbased security infrastructure. The result will provide identity federation and attributebased policy enforcement for Grids that leverages the Shibboleth system being deployed on campuses. We provide an overview of both Shibboleth and the Globus Toolkit, present our motivating u...

Globus pallidus neurons receive GABAergic input from the caudate-putamen via the striatopallidal pathway. Anatomical studies indicate that many CB(1) cannabinoid receptors are localized on terminals of striatopallidal axons. Accordingly, the hypothesis of the present work was that activation of CB(1) receptors presynaptically inhibits neurotransmission between striatopallidal axons and globus p...

GridFTP is a high-performance, reliable data transfer protocol optimized for high-bandwidth wide-area networks. Based on the Internet FTP protocol, it defines extensions for highperformance operation and security. The Globus implementation of GridFTP provides a modular and extensible data transfer system architecture suitable for wide area and high-performance environments. GridFTP is the de fa...