نتایج جستجو برای: global brain ischemia

تعداد نتایج: 974514  

Objective(s): Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. Materials and Methods: Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusio...

Journal: :European journal of pharmacology 2002
Eduardo Candelario-Jalil Dalia Alvarez Armando González-Falcón Michel García-Cabrera Gregorio Martínez-Sánchez Nelson Merino Attilia Giuliani Olga Sonia León

Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global cerebral ischemia in gerbils. Administration of ...

Journal: :Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 1993

Journal: :Stroke 1994
P J Hoehner J R Kirsch M A Helfaer T F Ganunis M T Murphy R J Traystman

BACKGROUND AND PURPOSE Voltage-dependent calcium channels (VDCCs) are thought to play a major role in the alteration of calcium homeostasis during ischemia. Tissue functional state as well as responsiveness to therapy with calcium channel blockers may be a function of regional changes in the density of VDCCs. This study determined whether VDCCs are altered by global ischemia in infant and adole...

Journal: :Stroke 1990
D J Combs R J Dempsey M Maley D Donaldson C Smith

The dose-response relation between plasma glucose and brain lactate and the relation of these parameters to intracellular pH during severe cerebral ischemia have not been well characterized over a wide range of plasma glucose levels. Experiments to delineate these relations in the gerbil model of global ischemia were performed by using phosphorus-31 nuclear magnetic resonance spectroscopy to me...

Journal: :Stroke 1993
W D Dietrich O Alonso R Busto

BACKGROUND AND PURPOSE Clinical and experimental data indicate that hyperglycemia can aggravate the consequences of stroke and cerebral ischemia. The purpose of this study was to examine the effects of moderate hyperglycemia on the response of the blood-brain barrier to normothermic (37 degrees C) and hypothermic (30 degrees C) global forebrain ischemia. METHODS Sixteen rats underwent 20 minu...

Journal: :Stroke 1979
D L Jackson W P Dole

The pathophysiology of post-cardiac arrest brain damage is not well understood. Many of the model systems presently used to study global ischemia have serious limitations. A new model system for total cerebral ischemia (TCI), using aortic and inferior vena caval occlusion balloons, is described. This model system produces verifiable TCI and avoids surgical invasion of the thorax or the use of v...

اسکندری, مهدی, بیگدلی, محمد رضا, غلام‌زاده, راهله, مصطفوی, حسین,

Background and Objective: One of the major side effects of cerebral ischemia is the water content enhancement in brain tissues which leads to mortality enhancement. Recently, therapeutic strategies have been focusing on preconditioning mechanisms. Erythropoietin as a glycoprotein hormone with anti-inflammatory and antioxidant effects on brain may be effective on brain edema reduction. Mate...

Ali Shamsizadeh, Mohammad Allahtavakoli, Mohammad Ebrahim Rezvani Ruhollah Moloudi

Objective(s) Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. Materials and Methods Addiction was induced by progressive incremental doses of morphine over 7 days. Behavioral si...

Journal: :Stroke 1994
U Dirnagl K Niwa G Sixt A Villringer

BACKGROUND AND PURPOSE We tested the hypothesis that cerebral hypoperfusion after experimental global cerebral ischemia is caused by plugging of the microcirculation with activated leukocytes using in vivo microscopic observation of the behavior of leukocytes in the cortical microcirculation during the transition from postischemic hyperperfusion to hypoperfusion. METHODS Anesthetized and vent...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید