Purpose: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer, and whether Gp3 tumors progress directly to Gp4, remain to be established.Experimental Design: Whole-exome sequencing and transcriptome profiling of laser capture-microdissected adjacent Gp3 and cribiform Gp4 were used to determine the...

BACKGROUND Prostate cancer is the second most common malignancy among men worldwide and the sixth cause of cancer-related death. Some authors have reported a relationship between perineural invasion (PNI), Gleason score, and the invasion of peripheral organs during prostatectomy. However, it is not yet clear whether pathological evidence of PNI is necessary for risk stratification in selecting ...

This study was designed to define possible preoperative predictors of positive surgical margin after laparoscopic radical prostatectomy. We retrospectively analyzed the records of 296 patients with prostate cancer diagnosed by prostate biopsy, and eventually treated with laparoscopic radical prostatectomy. The prognostic impact of age, prostate volume, preoperative prostate-specific antigen, bi...

Intermediate risk disease Pathological status: PSA 10–20 ng/mL, or biopsy Gleason score 7, or clinical stage T2b or T2c Clinical note: Heterogeneous group with a wide incidence of biochemical relapse & numerous curative therapy options. Problems with categorization: Detection of unfavourable subgroup includes Gleason ≥4+3 and/or >50% positive biopsies and/or >1 intermediate risk factors [1,2] R...

INTRODUCTION Positive surgical margins (PSMs) are an adverse factor that may predict a worse outcome in patients submitted to radical prostatectomy (RP). However, not all of these cases will evolve to biochemical (BCR) or clinical (CR) recurrence, therefore relationship between PSMs and these recurrent events has to be correlated with other clinical and pathologic findings to indicate complemen...

PCA3 (prostate cancer gene 3) and multiparametric 3 tesla MRI are new promising diagnostic tools in the detection of PCa. Our aim was to study the clinical value of the Progensa PCA3-test: its predictive value for biopsy outcome, Gleason score and MRI outcome. We evaluated, retrospectively, 591 patients who underwent a Progensa PCA3-test at the Radboud University Nijmegen Medical Centre between...

OBJECTIVE To determine whether there are subsets of men with pathological high grade prostate cancer (Gleason score 8-10) with particularly high or low 2-year biochemical recurrence (BCR) risk after radical prostatectomy (RP) when stratified into groups based on combinations of pathological features, such as surgical margin status, extracapsular extension (ECE) and seminal vesicle invasion (SVI...

OBJECTIVES HistoScanning™ (HS) is a method of ecographic diagnosis of prostate cancer. We analyze the effectiveness of the HS realization prior to the biopsies for the prostate adenocarcinoma diagnosis. MATERIAL AND METHODS From August to October 2012 we have carried out a study with HS prior to the biopsies in 32 patients. In all cases sextants transrectal biopsies have been realized (two co...

CONTEXT The format of a synoptic report can significantly affect the accuracy, speed, and preference with which a reader can retrieve information. OBJECTIVE The objective of this study is to compare different formats of Gleason grading/score in synoptic reports of radical prostatectomies. METHODS The performance of 16 nonpathologists (cancer registrars, MDs, medical non-MDs, and nonmedical)...

The aim of this study was to analyse the relationship between the expression of the bcl-2 proto-oncogene and the histological grading of prostate cancer according to the Gleason score. To study the prognostic significance of Bcl-2 over expression in prostate cancer, 36 consecutive radical prostatectomy specimens were examined by immunohistochemistry. Bcl-2 was associated with malignant phenotyp...