BACKGROUND Growth hormone-releasing peptides (GHRPs) constitute a group of small synthetic peptides that stimulate the growth hormone secretion and the downstream axis activity. Mounting evidences since the early 1980s delineated unexpected pharmacological cardioprotective and cytoprotective properties for the GHRPs. However, despite intense basic pharmacological research, alternatives to preve...

In previous in situ and in vivo rat perfusion studies, the intestinal absorption of several low molecular weight drugs was increased by the presence of luminal D-glucose. The intent of this study was to determine the potential of this fed-state effect to improve the intestinal uptake of poorly permeable, small peptide and peptide-like drugs. Jejunal wall permeabilities (Pw*) of di-(D-kyotorphin...

Ghrelin and obestatin are two proteins that originate from post-translational processing of the preproghrelin peptide. Various authors claim an opposed role of ghrelin and obestatin in several systems. Preproghrelin mRNA is significantly expressed in airway epithelium throughout lung development, predominantly during the earliest stages. The aim of this study was to evaluate the role of ghrelin...

Main goal of the German Collaborative Research Center (GCRC) is to build an anthropomorphic robot which is able to cooperate with humans. It addresses scientific problems in four different fields: humanoid mechatronics, multimodal interfaces, man-machinecooperation and machine-learning. Among those, natural, multimodal interaction is a key issue of humanoid robots since a human-like appearance ...

The extended a (aE) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional a chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (aEC). A recombinant form of aEC (raEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris) and purified by anion exchange column chromatography. Purified raEC ...

As a regulator of food intake and energy metabolism, the role of ghrelin in glucose metabolism is still not fully understood. In this study, we determined the in vivo effect of ghrelin on incretin effect. We demonstrated that ghrelin inhibited the glucose-stimulated release of glucagon-like peptide-1 (GLP-1) when infused into the portal vein of Wistar rat. Hepatic vagotomy diminished the inhibi...

The work is devoted to the analysis of reactive changes in ghrelin-producing endocrine cells (HPEC) main areas production this regulatory peptide – stomach and hypothalamus during modeling psycho-emotional stress after replacement therapy. Reactive HPECs experimental post disorder models have not previously been specifically studied. Meanwhile, practice establish effectiveness therapeutic inter...

Ghrelin is a peptide released from gastric endocrine cells that has an orexigenic effect via a vagal pathway. Here we determine the effect of ghrelin on mechanosensitivity of upper-intestinal vagal afferent fibers in ferret and mouse. The responses of gastroesophageal vagal afferents to graded mechanical stimulation were determined in vitro before and during application of ghrelin to their peri...