To examine the effect of increased hexosamine flux in liver, the rate-limiting enzyme in hexosamine biosynthesis (glutamine:fructose-6-phosphate amidotransferase [GFA]) was overexpressed in transgenic mice using the PEPCK promoter. Liver from random-fed transgenic mice had 1.6-fold higher GFA activity compared with nontransgenic control littermates (276 +/- 24 pmol x mg(-1) x min(-1) in transge...

The goal of many early visual filtering processes is to remove noise while at the same time sharpening contrast. An historical succession of approaches to this problem, starting with the use of simple derivative and smoothing operators, and the subsequent realization of the relationship between scale-space and the iso-tropic diffusion equation, has recently resulted in the development of " geom...

Approximate message passing (AMP) is an effective iterative sparse recovery algorithm for linear system models. Its performance is characterized by the state evolution (SE) which is a simple scalar recursion. However, depending on a measurement matrix ensemble, AMP may face a convergence problem. To avoid this problem, orthogonal AMP (OAMP), which uses de-correlation linear estimation and diver...

Diffusion MRI (dMRI) is the unique technique to infer the microstructure of the white matter in vivo and noninvasively, by modeling the diffusion of water molecules. Ensemble Average Propagator (EAP) and Orientation Distribution Function (ODF) are two important Probability Density Functions (PDFs) which reflect the water diffusion. Estimation and processing of EAP and ODF is the central problem...

Since the 2016 Brexit referendum a series of crises has gripped Northern Ireland's politics. This had destabilising effect across society, which arguably been felt most acutely by political unionism. The Belfast/Good Friday Agreement (B/GFA) 1998 created institutions to deal with conflict in Ireland, manage cross-border cooperation and normalise relations between UK Ireland. However, many aspec...

The Ni-free Ti-based bulk metallic glasses (BMGs) with high glass-forming ability (GFA) can be synthesized in the (Ti, Cu, Zr)92.5Fe2.5Sn2Si1Ag2 alloy system over a wide composition range by copper-mold casting. Especially, Ti48Cu37Zr7.5Fe2.5Sn2Si1Ag2 glassy form BMG rod diameter up to 6 mm and showed compressive strength of ~ 2.05 GPa, elastic modulus 100 microhardness 571 Hv. BMGs presented g...

In recent times, energy performance assessment has gained a legislative imperative in that it constitutes an indispensable criterion for preparing Energy Performance Certificates (EPCs). Accordingly, production of EPC which is heralded by energy audits and simulations using BIM software programs heavily depends on data accuracy. Whereas, there have been several studies on Building Information M...

With reference to brownfield sites redevelopment interventions, an innovative model for the definition of effective and financially sustainable initiatives is proposed tested. The borrows operative logic break-even analysis (BEA). It neglects basic assumption BEA related revenue linearity, by considering real trend revenues. In fact, in specific contexts characterized a estate over supply—e.g.,...

The aim of this article is to examine the relationship between trust, testimony and truth recovery processes as part of post-conflict transition. The paper uses the case study of unionist attitudes toward a community-based truth-telling project in Northern Ireland to demonstrate the impact an absence of trust can have upon what the French philosopher Paul Ricoeur has described as the ‘space of ...