Testicular germ cell tumors, though rare (1%), represent the most common neoplasm among young men. Gastrointestinal involvement from these malignancies usually presents as bowel obstruction and digestive bleeding, but their frequency is low (5%). The patterns of this involvement are: infiltration from affected retroperitoneal lymph nodes or, less frequently, by peritoneal seeding and direct hem...

Primordial germ cell development uses programmed cell death to remove abnormal, misplaced or excess cells. Precise control of this process is essential to maintain the continuity and integrity of the germline, and to prevent germ cells from colonizing locations other than the gonads. Through careful analyses of primordial germ cell distribution in developing Drosophila melanogaster embryos, we ...

BACKGROUND Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the steroidogenic effects of phthalates, the effects on germ cells have been less explored. OBJECTIVES We sought to identify the effects of phthalate exposure on human fetal germ cells in a dynamic model and to establish whether...

In this study we show that mouse primordial germ cells and fetal germ cells at certain stages of differentiation express E-cadherin and alpha and beta catenins. Moreover, we demonstrate that the formation of germ cell aggregates that rapidly occurs when monodispersed germ cell populations are released from embryonic gonads in culture is E-cadherin mediated, developmentally regulated, and depend...

retroperitoneal lymph node biopsy which revealed no evidence of malignancy, but detected 4–5 mm tumor necrosis foci in some areas. The patient followed by three cycles of chemotherapy with bleomycin, etoposide, and cisplatin protocol. Follow-up CT after chemotherapy revealed that the para-aortic lymphadenopathies had decreased in size to 3.4 cm × 2 cm × 1.6 cm. The patient then underwent a retr...

Defining normal and malignant germ cell development is crucial for understanding the biology and behavior of germ cell tumors. Germ cell tumors show significant similarities with immature germ cells. Furthermore, treatment sensitivity of germ cell tumors reflects the intrinsic characteristics of the cell of origin, and their derivatives. The aim of this thesis was to identify factors involved i...

hyalinizying clear cell carcinoma is a rare tumor which affects women more than men and is more common in minor salivary glands. the purpose of this paper was to describe a case of hyalinizing clear cell carcinoma of buccal vestibule in a 55-year-old woman. it is important to differentiate this neoplasm from other tumors with clear cell features because of their differences in treatment and cli...