Pseudomonas aeruginosa is one of the most virulent and frequently encountered infectious agents affecting the cornea (Allen and Mangiaracine, 1964). Unhappily, its destructive effect on ocular tissues cannot always be prevented by the antibiotics currently available. The best anti-Pseudmonas drugs are colistin, polymyxin B, and gentamicin (Burns, 1969; Gordon, 1970), but Pseudomonas strain-resi...

BACKGROUND Renal failure is an increasingly common condition with limited treatment options that is causing a major financial and emotional burden on the community. Andrographis paniculata is the plant used in Ayurveda for several remedies. Scientific evidence suggests its versatile biological functions that support its traditional use in the Orient. The plant is claimed to possess immunologica...

Problem statement: The Amino glycoside antibiotics cause drug induced nephrotoxicity at therapeutic doses and thus limits the use clinically. Oxidative stress is one of the main reasons for the development of nephrotoxicity. Approach: In light of this the aim of the present study was to investigate the role of mitochondrial as well as post-mitochondrial oxidative stress in the development of Ge...

The specificity of gentamicin for vitamin E deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. To determine the ways in which vitamin E manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

Objective(s):To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. Materials and Methods: Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum a...

This study determined the sensitivity of 12 independent isolates of cultured human proximal tubule (HPT) cells to gentamicin. The TD50 (dose [microgram per ml]) for each isolate was determined by linear regression analysis of cells exposed to a wide concentration range of gentamicin over a 16-day period of exposure. The results of this determination clearly showed that within a series of HPT ce...