OBJECTIVE The present study investigated the clinical significance of mannose-binding lectin 2 (MBL2), cluster of differentiation 14 (CD14) and tumour necrosis factor-α (TNF-α) gene polymorphisms in patients with spinal tuberculosis (TB) in Chinese population. METHODS A total of 240 patients with spinal TB were enrolled in the present study from May 2013 to August 2016 at Hangzhou Red Cross H...

OBJECTIVE To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor (CCR5 gene) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects. RESEARCH DESIGN AND METHODS A total 616 Japanese subjects with type 2 diabetes were recruited. Polymorphisms of -28 C/G and -403 G/A in the RANTES gene promoter region, and of 59029 G/A in the CCR5 gene promot...

objective(s) primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. lactase non-persistence is inherited as an autosomal recessive trait. a dna variant, single nucleotide polymorphism c/t−13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (lct) at chromosome 2 has been...

BACKGROUND IL28B polymorphism is recognized as one of the most prominent predictors of hepatitis C spontaneous and treatment-induced clearance. Interestingly, the favorable genotypes of IL28B are found to be more frequent in Asian ethnicity than Caucasian and African populations, respectively. A few studies reported that there is a mysterious association between the IL28B polymorphism and the h...

Genotypes A and D of the hepatitis B virus were found to be prevalent among 278 chronic carriers residing in Spain, and genotypes B, C, E and F were detected with significant frequency (9%). Two genotype E infections corresponded to carriers born in Spain who had never traveled to Africa. These results indicate that genotype E is beginning to circulate in the Spanish population in the same way ...

Genotype C of hepatitis B virus (HBV) has been shown to be associated with a poor clinical outcome, compared to genotype B. To explore the clinical phenotypes, with special reference to the seroconversion of hepatitis B e antigen (HBeAg) and frequency of acute exacerbation between patients infected with HBV genotypes B and C, a cohort of 272 Taiwanese patients with chronic HBV infection was ana...