Background and purposeIonising radiation causes mutations in the genomes of tumour cells serves as a potent treatment for cancer. However, mutation signatures cancer genome following ionising have not been documented.Materials methodsWe established an vitro experimental system to analyse presence de novo irradiated (60 Gy/20 fr/4 weeks) oesophageal cell lines. Subsequently, we performed whole-g...

Cyclotides are cysteine-rich cyclic peptides that have various activities and applications. Mining at the whole-genome scale facilitates profiling development of cyclotide-based markers. However, characterization cyclotide subfamilies a genome-scale in plants is an untapped area needs more studies. Here we developed four degenerate subfamily-specific (CSS) markers based on their subfamily’s sem...

Infectious bronchitis virus (IBV) is a contagious pathogen in fowl that results in economic loss in the poultry industry. In this study, the amino acids sequences of three structural proteins M, N, and S1 for five Iranian IBV isolated during 1998-2011 have been analyzed. Conserved and variable regions, hydrophobic characteristics and identity matrix were determined after alignment by Bioedit ve...

We look to mitonuclear ecology and the phenomenon of Mother’s Curse argue that sex parents offspring among populations eukaryotic organisms, as well mitochondrial genome, ought be taken into account in conceptualization evolutionary fitness. Subsequently, we show how characterizations fitness considered by philosophers do not take genome may suffer. Last, reflect on debate regarding fundamental...

Abstract Plant breeding relies on the presence of genetic variation, which is generated by a random process mutagenesis that acts existing gene pools. This variation then recombined into new forms at frequencies impacted local euchromatin and heterochromatin environment. The result lottery where plant breeders face increasingly low odds generating “winning” genotype. Genome editing tools enable...