The Cochran-Armitage trend test is commonly used as a genotype-based test for candidate gene association. Corresponding to each underlying genetic model there is a particular set of scores assigned to the genotypes that maximizes its power. When the variance of the test statistic is known, the formulas for approximate power and associated sample size are readily obtained. In practice, however, ...

BACKGROUND "Precision medicine" (PM) requires researchers to identify actionable genetic risks and for clinicians to interpret genetic testing results to patients. Whether PM will equally benefit all populations or exacerbate existing disparities is uncertain. METHODS We ascertained attitudes toward genetic testing and genetic research by race in the United States using the online Amazon mTur...

Different studies have pointed out Navarre as one of the regions of Spain with the highest incidence rates of brain and other central nervous system (CNS) cancer. Trend analysis for cancer incidence rates for long periods of time, might help determining risk factors as well as, assessing prevention actions involved in this disease. The objective of this study was to describe the incidence of br...

BACKGROUND Intervertebral disc disease (IDD) is a hereditary condition particularly common in Dachshunds. The breed is predisposed to early intervertebral disc degeneration and intervertebral disc calcification (IDC). When calcified, these severely degenerated discs are visible in spinal radiographs. Since the number of calcified discs (NCD) is associated with IDD, spinal radiography can be uti...

This study investigated the use of Artificial Neural Network (ANN) and Genetic Algorithm (GA) for prediction of Thailand's SET50 index trend. ANN is a widely accepted machine learning method that uses past data to predict future trend, while GA is an algorithm that can find better subsets of input variables for importing into ANN, hence enabling more accurate prediction by its efficient feature...

A selection experiment was established in 1981 to increase twinning rate in cattle. Results reported are through 1993 calf crops. Estimates of genetic parameters for a two-trait twinning and ovulation rate model with genetic groups were as follows: heritabilities of .03 for twinning and .07 for ovulation rates with a genetic correlation of nearly 1.00 and fractional permanent environmental vari...

New Zealand dairy farmers use a number of performance indicators to describe their systems. Most of the performance indicators are scaled to a unit of feed or a proxy that relates a cow to a unit of feed, such as stocking rate or kilograms of live weight per tonne of feed. Genetic improvement of dairy cows can contribute to increasing the net income per unit of feed consumed. The current econom...

November 6, 2009 Type Package Title Robust tests for case-control genetic association studies Version 1.01 Date 2009-11-06 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. T...