Genetic susceptibility to infection and sepsis It seems obvious that there must be a genetic component to the susceptibility of individuals to infection and also sepsis. The key question revolves around the relevance of any data indicating that there are indeed recognisable genetic polymorphisms that predispose individuals to either becoming infected, or having a disproportionate response to a ...

In a given population, certain individuals are much more likely to have seizures than others. This increase in seizure susceptibility can lead to spontaneous seizures, such as seen in idiopathic epilepsy, or to symptomatic seizures that occur after insults to the nervous system. Despite the frequency of these seizure disorders in the human population, the genetic and physiological basis for the...

Viral susceptibility and disease progression is determined by host genetic variation that underlies individual differences. Genetic polymorphisms that affect the phenotype upon infection have been well-studied for only a few viruses, such as HIV-1 and Hepatitis C virus. However, even for well-studied viruses the genetic basis of individual susceptibility differences remains elusive. Investigati...

Aim. To identify risk factors for urticaria, to determine the relative proportion of the susceptibility to urticaria that is due to genetic factors in an adult clinical twin sample, and to further determine whether the genetic susceptibility to urticaria overlaps with the genetic susceptibility to atopic diseases. Methods. A total of 256 complete twin pairs and 63 single twins, who were selecte...

shigellosis is one of the important gastrointestinal bacterial infections, particularly among children of developing countries such as iran. antibiotic susceptibility pattern and genetic typing for epidemiological purposes are of significant issues in shigella infectious control. the aim of this study was to investigate the antibiotic susceptibility and genetic relationship among shigella strai...

The strategy of positional cloning has been highly successful in identifying a number of single gene disorders that exhibit clear Mendelian patterns of inheritance. Positional cloning of insulin-dependent diabetes mellitus (IDDM) has been assisted by the expansion of molecular genetic tools and highly informative markers, so that new IDDM susceptibility genes are being uncovered. The ultimate c...

Twenty percent of breast cancer cases may be related to a genetic mutation conferring an increased risk of malignancy. The most common and prominent breast cancer susceptibility genes are BRCA1 and BRCA2, found in nearly 40% of such cases. However, continued interest and investigation of cancer genetics has led to the identification of a myriad of different breast cancer susceptibility genes. A...

Osteoporosis is a multifactorial disease characterized by a decrease in bone mass and deterioration of bone architecture. Genetic factors are determinants of peak bone mass and may influence age-related decreases of bone mass. WHO has established an operational criterion based on bone density measuring, the T-score. 122 cases were studied, 51 diagnosed with primary osteoporosis. Mean age was 57...