Background Asthma is a complex disease due to the contribution of both genetic and environmental factors. Several genes and polymorphisms have been associated to asthma susceptibility and development, leading to distinct clinical patterns. The aim of this study was to analyze sixteen genetic polymorphisms in eleven genes previously associated to asthma in a Brazilian family-based population study.

In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference...

The most challenging strategy for analyzing genome-wide polymorphisms and/or expression profiles is to solve multi-factor causal-relationship simultaneously. As the first step, we propose a framework of association study using maximum likelihood method that simultaneously handles genetic polymorphisms and epi-genetic information, e.g. environmental factors. We evaluate the theory by applying it...

Genetic factors are supposed to account for about 30-50% of the predisposition to cocaine and heroin addiction. This study aims at investigating the effect of rs2281285, rs2235749, rs910080 and 68bp VNTR polymorphisms of prodynorphin (PDYN) gene on heroin dependence risk in a sample of the southeast Iranian population. This case-control study was done on 216 heroin dependence subjects and 219 h...

Polymorphisms are DNA variations between different individuals of the same species. There are several types of polymorphisms, including single nucleotide polymorphisms (SNPs), variable number tandem repeats, insertions and deletions, large-scale polymorphisms, and copy number variants. In addition to helping explain the genetic basis of our diversity, understanding polymorphisms is also medical...

Several molecular marks have been used for various purposes since the beginning of contemporary technology: Genetic resource characterization, core genetic collection, mapping, marker-assisted selection, and back crossing etc. The variety all plant species, their make-up, environments in which they dwell are considered to be components biological diversity. Plant classification identification c...

In the last decade, human diallelic InDel polymorphisms have become promising genetic markers in forensic identi?cation cases and biogeographic inference of biological samples [1,2]. InDels can be used successfully highly degraded DNA may play an important role as e? ;ective supplement for existing personal identi?cation. also a good choice population studies, parentage testing, missing person ...

Bronchopulmonary dysplasia (BPD) is the chronic lung disease of preterm infants and still represents a major burden of prematurity. Several clinical risk factors for the onset of the disease are already known. In addition, some candidate genes have recently been identified. We set out to determine clinical as well as genetic risk factors for the development of BPD in the German population. 155 ...

Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, n...