نتایج جستجو برای: genetic locus
تعداد نتایج: 656620 فیلتر نتایج به سال:
Specific-locus experiments have previously shown melphalan to be mutagenic in all male germ-cell stages tested and particularly so in early spermatids. All but 2 of 24 specific-locus mutations recovered were tested genetically, cytogenetically, and/or molecularly. At least 12 of 15 tested mutations recovered from postspermatogonial stages but only 1 of 7 mutations recovered from stem-cell or di...
A total of 58 mutations at the engrailed locus were isolated. Analysis suggests that this genetic locus is necessary for survival but required only in the cells of the posterior compartments. Inactivation of the engrailed locus renders the animal incapable of maintaining the separation between the groups of cells that constitute either the compartments that subdivide each segment or the individ...
We used strains carrying specific lacZ alleles to identify a new mutator locus in Escherichia coli which generates only G.C----T.A transversions among base substitutions. The locus, mutM, mapped near the cysE locus, which is at 81 min on the genetic map.
OBJECTIVE Simulated samples have been widely used in the development of efficient statistical methods identifying genetic variants that predispose to human genetic diseases. Although it is well known that natural selection has a strong influence on the number and diversity of rare genetic variations in human populations, existing simulation methods are limited in their ability to simulate multi...
Shared associations identify causal relationships between gene expression and immune cell phenotypes
Abstract Genetic mapping studies have identified thousands of associations between common variants and hundreds human traits. Translating these into mechanisms is complicated by two factors: they fall gene regulatory regions; are rarely mapped to one causal variant. One way around limitations find groups traits that share associations, using this genetic link infer a biological connection. Here...
Population structure in Arabidopsis lyrata: evidence for divergent selection on trichome production.
Leaf trichomes may serve several biological functions including protection against herbivores, drought, and UV radiation; and their adaptive value can be expected to vary among environments. The perennial, self-incompatible herb Arabidopsis lyrata is polymorphic for trichome production, and occurs in a glabrous and a trichome-producing form. Controlled crosses indicate that the polymorphism is ...
Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically consider a limited number of hypotheses, most of which are related to the effect of a single locus or of a relatively small number of neighboring loci on a chromosomal region. We have developed a novel method that is ...
Considering of multiples research genetic in cats, the objective this study was to compare diversity domestic cat population at different spatial and temporal scales. According administrative division city Cali, 8 colonies (localities) were chosen, which together form 5 subpopulations within for sampling. The phenotype from each individual?s coat recognized subsequent calculation allele frequen...
We consider genotypic convergence of populations and show that under fixed fitness asexual haploid sexual attain monomorphic (even genetic linkage between loci) to basins attraction with locally exponential rates; the same obtains in single locus diploid reproduction but polymorphic populations. Furthermore, we there is a unified theory underlying these convergences: all them can be interpreted...
Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits a...
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