This article is a great up to date review of the current knowledge of genetics of Alzheimer's disease and FTD. It provides a brief description of the biology of each disease and includes discusions of genetic associations for familial cases versus sporadic cases. It also discusses the currently known molecular mechanisms for each disease and provides clear explanations of proposed gene mechanisms.

As surgeons who care for patients with breast cancer, the possibility of a cancer diagnosis being related to a hereditary predisposition is always a consideration. Not only are we as surgeons always trying to identify these patients and families but also we are often asked about a potential hereditary component by the patients and their family members. It is therefore critical that we accuratel...

I n recent years, scientists have identified genetic mutations associated with a broad range of diseases, from rare conditions like Huntington's disease to certain forms of breas t and colon cancer. These discoveries, in turn , have prompted the rapid development of genetic testing. Two different kinds of genetic tests are now in use. Somatic tests aim to detect a current disease or to identify...

BACKGROUND Genetic counseling by a Genetic Counselor (GC) is a requirement prior to genetic testing for cancer susceptibility genes (GC-mandate policy) for some insurers. This study evaluated the impact of this policy from the patient perspective. METHODS Surveys were sent to individuals for whom their insurer ordered genetic testing for the cancer susceptibility genes BCRA1 and BRCA2 over a ...

Amniocentesis, and other prenatal genetic tests, have become a well-established feature of modern prenatal care. But these tests place a considerable decision-making burden on the expectant mothers to whom they are offered: the genetic issues involved are complex and the appropriate course of action sometimes ambiguous. Genetic counseling aims to help pregnant clients make an informed decision ...

INTRODUCTION Neonatal autopsy is a valuable, critical diagnostic method to provide genetic counseling for future pregnancies. POPULATION AND METHODS Retrospective study including all neonatal autopsies performed on deceased neonates at Clínica y Maternidad Suizo Argentina between January 1998 and December 2006. The rate of autopsies was established; the diagnosis indicated in the medical reco...

Background: Breast cancer is one of the most common malignancies among Iranian women; however, its clinicopathological feature is uncertain. We pioneered a genetic counseling program among patients with breast cancer and their families in Isfahan. This is the first report of this program. Methods: This was a descriptive cross-sectional study on women with breast cancer registered in Ala Cancer...

Background: Couples unable to conceive and bear children could feel deep disappointment, often leading depression. Infertility is one of the main reasons couples are not able have children. Genetic counseling role in infertility ranges from explanation about possible genetic causes infertility, pregnancy planning, advice for treatment. Case Presentation: A couple with 16 years was referred clin...