Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...

Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment. Furthermore, most in vitro experiments to select resistance to dolutegravir have resulted in few mutations of the integrase gene. We performed an in vitro dolutegrav...

monoamine oxidase (ec, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. abnormal action of the monoamine oxidase b has been associated with neurological dysfunctions including parkinson´s disorder. monoamine oxidase b inhibitors divulged that these agents were effective in the therapeutic management of parkinson's disease. understanding the interaction of...

a group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a cox-2 so2me pharmacophore at the para position of the c-2 or c-4 phenyl ring, in conjunction with a c-4 or c-2 phenyl (4-h) or substituted-phenyl ring (4-f,4-cl,4-br,4-ome,4-me, 4-no2), were designed for evaluation as selective cyclooxygenase-2 (cox-2) inhibitors. these target 5-oxo-1,4,5,6,7,8 hexahydroquino...

cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (ca). hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expression of plasm...

this study was aimed to evaluate the antioxidative and urease inhibitory properties of the extracts from citrullus colocynthis l. the extracts of the root and pulp of fruit were prepared by soxhlet apparatus in methanol as solvent. the antioxidative activities, including dpph radical scavenging activity, reducing power and total antioxidant activity were studied in vitro. the results showed tha...

the date palm fruit stalk borer is one of the most important pests of date palm in the world. biochemical properties of digestive proteases in oryctes elegans prell larvae were investigated in this research and optimal total proteolytic and trypsin activities were obtained at ph 9.0 and 11.0, respectively. activity staining of protease on sds-page showed one isoform. also, zymogram pattern of t...

Abstract Background Higher aldehyde dehydrogenases ( ALDH ) activity is one of the important signatures breast cancer appearance and has been associated with poor prognosis. ALDH1A3 over-expressed in patients. This study aims to analyze gene expression patterns 18 isozymes tissue samples. It carried out using a chip-based microarray, next-generation DNA sequencing ALDH2 following silico identif...

Abstract Contaminated salted shellfish were a suspected cause of the 2019 hepatitis A outbreak in Korea; however, no virus was detected by detection tests used. In this study, we investigated shortcomings these for identifying to serve as guide improvement tests. Salted washed and desalted before collecting mid‐guts testing. For verification method, first inoculated with norovirus then RT‐qPCR ...