background and objective: histopathological evaluation of granulosa cell tumors (gct) of the ovary may be confused morphologically with a wide variety of the tumors. immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. although it has been suggested that inhibin can be a sensitive marker for gct, it maybe had negative results in some cases.  in addition, cal...

Granular cell tumors (GCT) are rare and unusual tumors, which are usually benign and asymptomatic. Only 5-10% of cases involve the gastrointestinal tract, most commonly as singular, non-cancerous lesions in the esophagus. We report a rare case of symptomatic, multifocal, synchronous GCT involving the esophagus, stomach, and cecum.

Giant cell tumor (GCT) of the bone, also called osteoclastoma, is a rare complication of Paget's bone disease. We report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. The natural history and the therapeutic outcomes of this unique complication of Paget's bone disease are presented.

OBJECTIVE We investigated the relationship between maternal circulating fatty acids (FAs) and dietary FA intake in pregnant women with gestational diabetes mellitus (GDM; n = 49), women with hyperglycemia less severe than GDM (impaired glucose challenge test [GCT] non-GDM; n = 80), and normal control subjects (n = 98). RESEARCH DESIGN AND METHODS A case-control design was nested within a pros...

The growth of human eosinophil progenitors (CFU-Eo) and the modulation of growth by hydrocortisone were studied as functions of the presence of lymphocytes and monocytes in marrow cells under study; and the source of colony-stimulating factors, specifically, media conditioned by macrophage-like cell line, GCT; phytohemagglutinin-stimulated mononuclear cells (PHA-LCM); or the T cell line, MO. CF...

A major barrier towards the study of the effects of drugs on Giant Cell Tumor of Bone (GCT) has been the lack of an animal model. In this study, we created an animal model in which GCT stromal cells survived and functioned as proliferating neoplastic cells. A proliferative cell line of GCT stromal cells was used to create a stable and luciferase-transduced cell line, Luc-G33. The cell line was ...

PURPOSE To review the functional outcome and local recurrence rate of 29 patients who underwent segmental excision or intralesional curettage with adjuvant therapy for giant cell tumour (GCT) of bone. METHODS Records of 17 men and 12 women (mean age, 30.17 years) who underwent segmental excision (n=18) or intralesional curettage followed by adjuvant therapy (n=11) for GCT of the femur (n=13),...

<p>Giant cell tumour (GCT) of bone is a benign but locally aggressive with the potential malignant transformation that mostly involves meta-epiphyseal region long bones. A 34-year-old female was presented to our institute progressive pain and swelling in her right knee radiologically histologically found have GCT proximal tibia. She treated extended curettage power burr, intra-lesion phen...

Giant cell tumor (GCT) of bone, the most common benign locally aggressive bone tumor, accounts for 4% to 5% all primary neoplasms and 20% tumors. The distal radius is third commonest site involvement in about 10% GCT cases. Due high recurrence rate after curettage more progressed lesions, surgeons prefer en bloc resection followed by reconstruction. Cases: Three Campanacci III cases underwent w...

ABSTRACT Introduction: Denosumab is a human monoclonal antibody that binds to the receptor activator of nuclear factor kB (RANKL), it used in treatment Osteoporosis. The Giant Cell Tumor (GCT) and Aneurysmal Bone Cyst (ABC) use same RANKL, for this reason drug began be its treatment. There consensus on use, dose-time 12-month duration GCT. Not so ABC. In unresectable, disabling or recurrent tum...