Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomized clinical trials in Europe.

We propose using the Global Dynamic Critical Path to diagnose system-wide bottlenecks using representative benchmarks to direct embedded SoC optimizations. We provide real-world experience of implementing the global critical path (GCP) analysis framework on a GloballyAsynchronous Locally-Synchronous (GALS) SoC built around the LEON3 CPU. We perform our analysis at the RTL level and extend our e...

BACKGROUND TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β i...

The orthorectification of satellite images is a foundational process in satellite applications. With the improvement of the satellite imaging technology and the orthorectification calculation models, the collection of Ground Control Point (GCP) is becoming the key factor restricting the efficiency and precision of orthorectification. At the same time, the services based on web in the geographic...

Nodifferencewas detected on the performances of construction heuristics for TSP developed in Task 1 between Euclidean instances with points uniformly sparse and Euclidean instances with points clustered. Attention was given to the choice of data structures to represent and maintain a solution during a perturbative search. We described Tabu Search (TS) and its variations: robust and reactive. We...