Voltage-gated ion channels play a fundamental role in the generation and propagation of the cardiac action potential by acting synergistically to produce an ionic current across cellular membranes. Abnormalities of heart ion channel activities that lead to loss or gain of function (channelopathies) are often associated with disruption of the coordinated propagation of electrical activity of the...

Quantitative four-dimensional (4D) image reconstruction methods with respiratory and cardiac motion compensation are an active area of research in ECT imaging, including SPECT and PET. They are the extensions of three-dimensional (3D) statistical image reconstruction methods with iterative algorithms that incorporate accurate models of the imaging process and provide significant improvement in ...

In the past few years, there has been an increasing interest of the radiation oncology community in cone-beam computed tomography (CT) scanners integrated into the gantry of medical linear accelerators. This imaging device allows to acquire CT images of the patient in treatment position. Unfortunately, like for other CT scanners, the respiratory motion of the patient during acquisition causes a...

OBJECTIVES To evaluate the relationship between serial cardiac troponin T (cTnT) levels with infarct size and left ventricular ejection fraction by gated single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in patients with acute myocardial infarction (AMI). BACKGROUND Current guidelines recommend the use of cTnT as the biomarker of choice for the diagnosis of A...

with the arrival of increasingly higher resolution pet systems, small amounts of motion can cause significant blurring in the images, compared to the intrinsic resolutions of the scanners. in this work, we have reviewed advanced correction methods for the three cases of (i) unwanted patient motion, as well as motions due to (ii) cardiac and (iii) respiratory cycles. for the first type of motion...

  Objective: IQSPECT is an advanced high-speed SPECT modality for performing myocardial perfusion imaging (MPI), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. The aim of this study was to compare IQSPECT compared with conventional SPECT interms of performance based on standard clinical protocols. In addition, we examined the concordance between convention...

With the arrival of increasingly higher resolution PET systems, small amounts of motion can cause significant blurring in the images, compared to the intrinsic resolutions of the scanners. In this work, we have reviewed advanced correction methods for the three cases of (i) unwanted patient motion, as well as motions due to (ii) cardiac and (iii) respiratory cycles. For the first type of ...

the thomas-fermi (tf) equation has proved to beuseful for the treatment of many physical phenomena. in this pa-per, the traveling wave solutions of the kdv equation is investi-gated by the simplest equation method. also, the effect of differentparameters on these solitary waves is considered. the numericalresults is conformed the good accuracy of presented method.

BACKGROUND To compare retrospectively generated gated plans to conventional internal target volume (ITV)-based plans and to evaluate whether gated radiotherapy provides clinically relevant dosimetric improvements to organs-at-risk (OARs). METHODS Evaluation was performed of 150 stereotactic ablative radiotherapy treatment plans delivered to 128 early-stage (T1-T3 (<5 cm)) NSCLC patients. To g...