A technique for determining pepsinogen group I (PGI) concentrations in endoscopic gastroduodenal biopsies is described and validated. This method has a good precision (intra-assay CVs 4.1% to 8.4%; between-assay CVs 4.6% to 9.3%), and analytical recovery is satisfactory (94% to 102%). Results were uninfluenced by the storage interval of the samples. At PGI-producing sites (i.e., fundus, corpus)...

Helicobacter Pylori infection has been identified as a pathogenic factor in a number of gastroduodenal diseases, most importantly in gastric and duodenal ulcer disease. This association and the development of H. PYLORI eradication therapies has had a tremendous influence on the surgical therapy for these disorders. Decades ago, surgery was the therapy of choice for gastric and duodenal ulcers. ...

Objective—To investigate the use of TcHMPAO (hexamethyl propylene amine oxime) leucocyte scintigraphy as a noninvasive screening test for inflammatory bowel disease. Patients—10 children with suspected Crohn’s disease, in whom routine investigation using barium contrast radiology, upper gastrointestinal endoscopy, colonoscopy, and mucosal biopsies had identified severe gastroduodenal and/or jej...

Although infrequently symptomatic, celiac artery stenosis is a vascular pathology that can commonly be encountered in hepatobiliary surgery. Secondary to celiac artery stenosis, the supramesocolic viscera may rely on blood supply from the gastroduodenal artery which, if ligated, can lead to detrimental ischaemia causing postoperative morbidity and mortality. We report the case of a 53-year-old ...

The knowledge of abdominal vascular anatomy is very important for surgeons and radiologists to perform many of the clinical diagnostic evaluations. The celiac trunk, one of the branches of the abdominal aorta shows numerous variations in its branching pattern and its branches. The present study is to demonstrate the rare branching pattern of celiac trunk, into hepatogastric and hepatosplenic tr...

Postpancreatectomy hemorrhage (PPH) and pancreatic fistula are main and serious complications following pancreaticoduodenectomy. Postpancreatectomy hemorrhage is considered life-threatening for its high rate of mortality. Postpancreatectomy hemorrhage is defined as early, occurring within 24 h after surgery, and late. The authors present a case of late PPH which developed in the third week foll...

PURPOSE OF REVIEW This article reviews selected publications related to nonsteroid anti-inflammatory drug (NSAID)-induced gastroduodenal toxicity in recent years. RECENT FINDINGS This article provides a comprehensive review of the latest evidence on the epidemiology of NSAID-induced gastroduodenal injury, recommendations on optimal gastroprotective regimens among patients in need of NSAID, ri...

Oxidative stress is a major cause of the gastrointestinal damage under physical or psychological stress. Ghrelin exhibits gastroprotective effects and they are supposed to be derived from antioxidant effects. In gastroduodenal mucosal injury, the plasma ghrelin levels increase in response to the demand for gastroduodenal cytoprotection. However, in the condition of Helicobacter pylori-induced g...