The gastrointestinal (GIT) segment wherein dietary additives, such as butyrate, are released may influence their observed efficacy. Release kinetics are influenced by pH, gastric and enteric motility, retention time in the different GIT segments and enzymes concentration. Unfortunately, none of the available in vitro poultry model mimics accurately these conditions. As a consequence, a novel in...

Brian R. Davis, MD, FACS, FASGE1 Alejandro Rios Tovar, MD1 Irene Sarosiek, MD, AGAF, FACG2 Richard W. McCallum, MD, FACP, FRACP, FACG, AGAF2 1Texas Tech University Health Sciences Center Paul L. Foster School of Medicine Department of Surgery and 2Department of Internal Medicine, El Paso, TX Early diagnosis and treatment of gastroparesis eludes pharmacologic solutions. Gastroparesis starts as a...

Helicobacter pylori induces the antiapoptotic protein myeloid cell leukemia 1 (Mcl1) in human gastric epithelial cells (GECs). Apoptosis of oncogenic protein Mcl1-expressing cells is mainly regulated by Noxa-mediated degradation of Mcl1. We wanted to elucidate the status of Noxa in H. pylori-infected GECs. For this, various GECs such as AGS, MKN45, and KATO III were either infected with H. pylo...

A 67 year old man with a clinical diagnosis of attenuated familial adenomatous polyposis (AFAP) and a past history of synchronous colon cancers in the transverse colon was also found to have an intraductal papillary mucinous neoplasm (IPMN) of the pancreas. In addition, several foci of heterotopic gastric oxyntic mucosa were noted in the duodenum, interspersed with flat and polypoid adenomas. T...

abstract background: esophageal replacement is indicated in certain circumstances including long gap esophageal atresia, severe strictures due to gastro-esophageal reflux (ger) and caustic burns. we analyzed our results of 18 patients who underwent esophageal replacement in our university hospital. methods: we reviewed esophageal replacements carried out in our department between june 1996 and ...

When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve oral delivery of NCs to treat gastrointestinal (GI) pathologies or for systemic absoption. However, GI instability of targeting moieties compromises this strategy. We explored whether encapsulation of antibody-coated NCs in microcapsules would protect...

The simultaneous effects of the cytochrome P450 inhibitor 1-aminobenzotriazole (ABT) on inhibition of in vivo metabolism and gastric emptying were evaluated with the test compound 7-(3,5-dimethyl1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole(NVS-CRF38), a novel corticotropin releasing factor receptor 1 (CRF1) antagonist with low water solubility, and the ...

chronic disease was referred to our hospital because of progressive abdominal distention and poor appetite in September 2009. He had undergone endoscopic submucosal dissection (ESD) at our endoscopy center for a large, flat lesion in the gastric incisure 2 months previously. The lesion had been a type IIb with a diameter of 10 cm. It had been resected in one piece and was shown histologically t...