نتایج جستجو برای: gap junction communication

تعداد نتایج: 521782  

Journal: :Frontiers in bioscience : a journal and virtual library 2001
G M Kidder E Winterhager

Gap junctions are sites where intercellular membrane channels are clustered that allow neighboring cells to pass small molecules directly between them. Gap junctional intercellular communication has been implicated in a variety of human diseases. Gap junction channels are assembled from a large family of proteins called connexins with each type of channel having some unique properties. Preimpla...

Journal: :The Journal of Cell Biology 1987
D C Spray M Fujita J C Saez H Choi T Watanabe E Hertzberg L C Rosenberg L M Reid

Intercellular communication via gap junctions, as measured by dye and electrical coupling, disappears within 12 h in primary rat hepatocytes cultured in serum-supplemented media or within 24 h in cells in a serum-free, hormonally defined medium (HDM) designed for hepatocytes. Glucagon and linoleic acid/BSA were the primary factors in the HDM responsible for the extended life span of the electri...

Journal: :Mechanisms of Development 2003
Cynthia M. Coleman Rocky S. Tuan

Growth/Differentiation Factor 5 (GDF5) plays an important role in limb mesenchymal cell condensation and chondrogenesis. Here we demonstrate, using high density cultures of chick embryonic limb mesenchyme, that GDF5 misexpression increased condensation of chondroprogenitor cells and enhanced chondrogenic differentiation. These effects were observed in the absence of altered cellular viability o...

Journal: :Cell structure and function 1994
H Chiba N Sawada M Oyamada T Kojima K Iba S Ishii M Mori

We have recently shown that connexin 43 (Cx43), a major gap junction protein in osteoblasts, is expressed with an increase in cell density (CHIBA, H. et al. (1993). Cell Struc. Funct., 18: 419-426). In the present study, we examined what kinds of hormones and cytokines regulate the gap junction protein in osteoblastic cells, using a human osteoblastic cell line (SV-HFO) after reaching a conflue...

Journal: :Developmental dynamics : an official publication of the American Association of Anatomists 2000
M Levin M Mercola

Connexins are a family of proteins that assemble to form gap junction channels. Cell-cell communication through gap junctions mediates many important events in embryogenesis, including limb patterning, lens physiology, neuronal function, left-right asymmetry, and secretion from gland tissue. We studied the expression of connexin 30 (Cx30) in the Xenopus embryo and find that it is expressed in t...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Scott Boitano Zeenat Safdar Donald G Welsh Jahar Bhattacharya Michael Koval

Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and en...

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