The problem of cancer in childhood assumes increasing importance as other formerly killing diseases, notably infections, have been to a large extent conquered. In recent years malignant neoplastic disease has accounted for 15 to 20% of deaths from natural causes in children between the ages of I to 14 years in England and Wales, and similar figures have been obtained from other countries, inclu...

The problem of cancer in childhood assumes increasing importance as other formerly killing diseases, notably infections, have been to a large extent conquered. In recent years malignant neoplastic disease has accounted for 15 to 20% of deaths from natural causes in children between the ages of I to 14 years in England and Wales, and similar figures have been obtained from other countries, inclu...

Presacral ganglioneuroma is an extremely rare tumor of neural crest origin. To the best of our knowledge, less than 20 cases have been reported previously. The present study reports on a presacral ganglioneuroma, 10.5 × 8 × 4 cm in size, that was found incidentally in a 35-year-old man with prior history of diverticulitis. He was admitted to our hospital due to lower left abdominal pain. Abdomi...

Segmental jumping translocations are chromosomal abnormalities in treatment-related leukemias characterized by multiple copies of the ABL and/or MLL oncogenes dispersed throughout the genome and extrachromosomally. Because gene amplification potential accompanies loss of wild-type p53, we examined the p53 gene in a case of treatment-related acute myeloid leukemia (t-AML) with MLL segmental jump...

Ganglioneuroma (GN) of the gastroin-testinal (GI) tract is rare tumor composed of ganglion cells, nerve fibers, and supporting cells of the enteric nervous system. Diffuse ganglioneuromatosis is associated with multiple endocrine neoplasia IIB (MEN IIB), neurofibro-matosis type I (NF1, also known as von Recklinghausen disease), multiple cu-taneous or GI tract neurofibromatosis, and neurogenic s...

We report a 5-year boy presenting with pain in the lower chest and upper abdomen. On evaluation with computed tomography scan of the chest, he was found to have a large 16 x 14 cm posterior mediastinal mass compressing the inferior vena cava and liver, and shifting the heart to the opposite side. Tumor was approached via right postero-lateral thoracotomy and dissected off from esophagus, heart,...

Adrenal ganglioneuromas (GNs) constitute rare, differentiated tumors which originate from neural crest cells. GNs are usually hormonally silent and tend to be discovered incidentally on imaging tests. Adrenalectomy is the gold standard for the treatment of primary adrenal GNs. Nevertheless, preoperative differential diagnosis of GNs remains extremely challenging, and thus histopathological exam...

BACKGROUND/PURPOSE In infants, neuroblastoma has been known to spontaneously differentiate into a benign ganglioneuroma. Although several investigators have compared mass-screened with unscreened, disseminated with localized, and adrenal with retroperitoneal neuroblastoma, there are very few cross-comparisons of the above parameters. Herein, the authors report the maturation of mass-screened, l...

imaging tests performed for another reason, is the most commonly reported in the literature, this was an atypical case of ganglioneuroma. Its atypical features included its location, because only 20--30% of cases occur in the adrenal gland; age at presentation, as these are tumors that may occur in any age group, but more than 80% are reported in patients under 40 years of age, and more than ha...

Ganglioneuroma (GN) of colon is a rare tumor of gastrointestinal (GI) tract. GNs of GI tract are usually confined to colon particularly rectum. GNs are usually found incidentally but can be associated with MEN IIb, von Recklinghausen’s neurofibromatosis or Cowden syndrome. A 21-year-old female with past medical history of bulimia, bipolar disorder and hypothyroidism, who presented with complain...