Amphiphilically modified cyclodextrins may form various supramolecular aggregates. Here we report a theoretical study of the aggregation of a few amphiphilic cyclodextrins carrying hydrophobic thioalkyl groups and hydrophilic ethylene glycol moieties at opposite rims, focusing on the initial nucleation stage in an apolar solvent and in water. The study is based on atomistic molecular dynamics m...

Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host-guest interactions. As such, cyclodextrins are used as excipients for experimental therapeutics in vivo. We observed unanticipated modifications to bioluminescence imaging (BLI) signal intensity when 2-hydroxy-propyl-β-cyclodextrin (HPCD) was coinjected as an ex...

The interaction between zaleplon (ZAL) and different cyclodextrins in aqueous solutions was investigated by spectrofluorimetric and phase solubility studies. Stability constants determined by both methods showed that among natural cyclodextrins, β-cyclodextrin (βCD) formed the most stabile complex but its solubilizing efficiency was limited. Among βCD derivatives, the complex stability and solu...

Cyclodextrin (CD) are cyclic oligosaccharides consisting of glucopyranosyl units linked by α-(1,4) bonds. The widely used natural cyclodextrins are α-, βand γ-cyclodextrin consisting of 6, 7 and 8 glucopyranose units, respectively. The cyclodextrin molecules have a unique structure with a hydrophobic cavity and a hydrophilic surface which can form inclusion complex with a wide variety of guests...

Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...

The formation and structure of inclusion complexes of αand β-cyclodextrins with 2-chlorophenol (2CP), 3-chlorophenol (3CP), 4-chlorophenol (4CP), 2,4-dichlorophenol (24DCP), 2,6-dichlorophenol (26DCP) and 3,4-dichlorophenol (34DCP) have been studied by UV-VIS and 1H NMR spectroscopy. Both cyclodextrins were found to form 1 : 1 inclusion complexes. Binding constants estimated from titration stud...

Most drugs permeate biological membranes via passive diffusion and it is generally assumed that the main barrier is the lipophilic structure of the membrane. However, we have observed that the unstirred water layer adjacent to the membrane surface can in some cases be a barrier just as effective as the lipophilic membrane itself. Hydrophilic cyclodextrins can enhance drug delivery through biolo...

cyclodextrins (CDs) is a practical and economical way to improve the physicochemical and pharmaceutical properties of administered drug molecules. CDs can improve properties such as solubility, stability, and bioavailability of various drugs, thereby potentially serving as novel drug carriers. In addition, the hydrophobic and ionizable derivatives of CDs are being tested for use in the preparat...

Difenoconazole (DIF) is a representative variety of broad-spectrum triazole fungicides and liposoluble pesticides. However, the water solubility DIF so poor that its application limited in plant protection. In addition, conventional formulations always contain abundant organic solvents, which may cause pollution environment. this study, two DIF/cyclodextrins (CDs) inclusion complexes (ICs) were...