نتایج جستجو برای: galectin 1

تعداد نتایج: 2755360  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
James W Welsh Steven N Seyedin Maria Angelica Cortez Amit Maity Stephen M Hahn

Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.

ژورنال: :تعالی بالینی 0
رؤیا عطابخشیان roya atabakhshian department of laboratory medicine, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehranتهران میدان قدس ابتدای خیابان دربند دانشکده پیراپزشکی فریبا رایگان fariba raygan heart department, shahid beheshti hospital, kashan university of medical sciences, kashan, iranگروه قلب و عروق، بیمارستان شهید بهشتی کاشان، دانشگاه علوم پزشکی کاشان، ایران فرانک کازرونی faranak kazerouni department of laboratory medicine, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iranگروه علوم آزمایشگاهی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

نارسایی قلبی یکی از شایع ترین اختلالات قلبی عروقی است که به عنوان یک اختلال مزمن، پیش رونده و ناتوان کننده مطرح می باشد. شیوع و بروز این بیماری با افزایش سن بالا رفته، به طوری که در کشورهای غربی حدود 1 تا 2 درصد بزرگسالان از این بیماری رنج می برند. از سوی دیگر پیشرفت در اقدامات درمانی و جراحی سبب شده بیمارانی که از مرگ در اثر سکته قلبی جان سالم به درمی برند متعاقباً به نارسایی قلبی مبتلا شوند. ل...

2017
Laura C. van Vark Ivonne Lesman‐Leegte Sara J. Baart Douwe Postmus Yigal M. Pinto Rudolf A. de Boer Folkert W. Asselbergs Elly M. C. J. Wajon Joke G. Orsel Eric Boersma Hans L. Hillege K. Martijn Akkerhuis Michiel J. Nagelsmit Hans‐Peter Brunner‐La Rocca Gerard C.M. Linssen Willem F. Terpstra Anho H. Liem Alexander J. Wardeh Addy J.M. van Miltenburg Ewout J. van den Bos Stijn P.J. de Ridder

BACKGROUND Several clinical studies have evaluated the association between galectin-3 levels and outcome in patients with heart failure (HF). However, little is known about the predictive value of repeated galectin-3 measurements. This study evaluates the prognostic value of repeated time-dependent galectin-3 measurements in acute HF patients. METHODS AND RESULTS In the TRIUMPH (Translational...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Jennifer J Foster Kelli L Goss Caroline L S George Peter J Bangsund Jeanne M Snyder

In mice, alveolarization occurs during postnatal days 4 through 12, when secondary alveolar septae create thin-walled alveoli in the distal lung. We hypothesized that genes predominantly expressed in newly forming secondary alveolar septae influence the process of alveolarization. To address this hypothesis, tips of secondary alveolar septae were isolated from sections of postnatal day 6 mouse ...

2012
Kyung-Hee Kim Yong-Kyun Kwon Chong-Kwan Cho Yeon-Weol Lee So-Hyun Lee Sang-Geun Jang Byong-Chul Yoo Hwa-Seong Yoo

OBJECTIVES Many efforts have shown multi-oncologic roles of galectin-3 for cell proliferation, angiogenesis, and apoptosis. However, the mechanisms by which galectin-3 is involved in cell proliferation are not yet fully understood, especially in human colon cancer cells. METHODS To cluster genes showing positively or negatively correlated expression with galectin-3, we employed human colon ca...

Journal: :The Journal of biological chemistry 2009
Pablo Argüeso Ana Guzman-Aranguez Flavio Mantelli Zhiyi Cao Jessica Ricciuto Noorjahan Panjwani

Maintenance of an intact mucosal barrier is critical to preventing damage to and infection of wet-surfaced epithelia. The mechanism of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell surface. Here we investigate a new role for the carbohydrate-binding protein galectin-3 in stabilizing mucosal barriers through...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1999
G A Rabinovich C M Riera C E Sotomayor

Galectin-1 belongs to an evolutionarily conserved family of animal beta-galactoside-binding proteins, which exert their functions by crosslinking the oligosaccharides of specific glycoconjugate ligands. During the past decade, attempts to identify the functional role of galectin-1 suggested participation in the regulation of the immune response. Only in the last few years has the molecular mech...

2010
Ming-Shyan Huang Chih-Jen Yang Ying-Ming Tsai Ya-Ling Hsu Yuh-Jyh Jong Chih-Hsing Hung Po-Lin Kuo Jen-Yu Hung Shau-Ku Huang Shah-Hwa Chou Da-En Cheng

Journal: :ChemBioChem 2023

Seek a cell anchorage galectin bridge: Transforming the wildtype Galectin (Gal)-1 and -3 to tandem-repeat type variant via rational protein engineering enhanced cis-binding activity with O-Mannosylated core M1 glycopeptides of α-dystroglycan (DG). Furthermore, Gal-1 variants (but not Gal-3 variants) demonstrated trans-bridging prepared α-DG core-M1 glycoconjugates laminins in situ carbohydrate-...

2016
Nicolas Clementy Nazih Benhenda Eric Piver Bertrand Pierre Anne Bernard Laurent Fauchier Jean-Christophe Pages Dominique Babuty

Galectin-3 is a biomarker of fibrosis and atrial remodeling, involved in the mechanisms of initiation and maintenance of atrial fibrillation (AF). We sought to study the accuracy of galectin-3 level in predicting recurrences of AF after ablation. Serum concentrations of galectin-3 were determined in a consecutive series of patients addressed for AF ablation in our center. After a 3-month blanki...

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