Prospective gadolinium(III) MRI contrast agent precursors [Gd-TREN-1,2-HOPO] (1) [TREN-1,2-HOPO = tris[(1-hydroxy-2-oxo-1,2-dihydropyridine-6-carboxamido)ethyl]amine] and [Gd-TREN-bis(Me-3,2-HOPO)-1,2-HOPO] (2) have been synthesized and characterized by relaxometric measurements. The water proton relaxivity values of 1 and 2 (20 MHz and 25 degrees C) are 9.5 and 9.3 mM(-)(1)s(-)(1), respectivel...

Gadolinium-DTPA MR imaging (Gd-MR), unenhanced MR imaging, and contrast-enhanced CT studies were compared prospectively in six patients with surgically confirmed pituitary adenomas and three patients without sellar pathology to determine the utility of Gd-MR in the diagnosis of pituitary adenoma. In normal patients, the pituitary gland, cavernous sinus, and infundibulum enhanced by T1 shortenin...

N. Dahlström, T. B. Brismar, A. Persson, N. Albiin, Ö. Smedby Center for Medical Image Science and Visualization (CMIV), Linköping University Hospital, Linköping, Sweden, Department of Radiology, Hudiksvall Hospital, Hudiksvall, Sweden, Department of Radiology, Karolinska University Hospital Huddinge, Stockholm, Sweden Introduction: The gallbladder and in particular the bile ducts are readily d...

A technique for the simultaneous measurement of three vascular parameters: blood flow (Frho), blood volume (v(b)), and the capillary permeability-surface area product (PSrho) in breast tumors using dynamic contrast-enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T(1), rapid temporal sampling, measurement of the arterial ...

INTRODUCTION: Hepatocellular carcinoma (HCC) is the fifth most common liver neoplasm causing one million cancer deaths annually worldwide. MR diagnosis of HCC has been traditionally made by whole liver dynamic study using fast gradient echo sequence with non-specific extravascular extracellular gadolinium chelates. PURPOSE: In this study, we have tested if our newly developed blood pool contras...

INTRODUCTION: It is known that immobilization causes a reduction of glycosaminoglycan (GAG) in articular cartilage [1, 2]. Further, in-ovo paralysis by decamethonium bromide in developing chick embryos interferes with the formation of normal joint anatomy similar to arthrogryposis [3, 4]. However, the effect of immobilization on the GAG content of articular cartilage in the developing chick emb...

The method known as DIXON is imaging from two different echo times (TE), using the opposite phase of water and fat. Modified DIXON (mDIXON) is the method that is calculated from changing the opposing phases 'in' and 'opposed' phases of the actual measurement, to fit the theoretical value. We reviewed that the effect of the water-fat separation and contrast depended on the different flip angles ...

BACKGROUND Novel potential MR imaging contrast agents Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd-TCP), Gd-hematoporphyrin (Gd-H), Gd-DTPA-9.2.27 against melanoma, Gd-DTPA-WM53 against leukemia and Gd-DTPA-C595 against breast cancer cells were synthesized and applied to mice with different human cancer cells (melanoma MM-138, leukemia HL-60, breast MCF-7). The relaxivity, the biodistribution...