This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. With only limited high-level evidence for management of nasal and paranasal sinus cancers owing to low incidence and diverse histology, this paper provides recommendations on the work up and management based on the existing evidence base. Recommendations • Sinon...

Extracellular stimuli exert their effects on eukaryotic cells via serpentine G-protein-coupled receptors and mediate a vast number of physiological responses. Activated receptors stimulate heterotrimeric G-proteins, consisting of three subunits, alpha, beta and gamma. In Dictyostelium discoideum, cAMP binds to the cAMP receptor cAR1, which is coupled to the heterotrimer containing the Galpha2 s...

Given a plane graph G, we wish to nd a drawing of G in the plane such that the vertices of G are represented as grid points, and the edges are represented as straight-line segments between their endpoints without any edge-intersection. Such drawings are called planar straight-line drawings of G. An additional objective is to minimize the area of the rectangular grid in which G is drawn. In this...

Given a distribution of pebbles on the vertices of a graph G, a pebbling move takes two pebbles from one vertex and puts one on a neighboring vertex. The pebbling number Π(G) is the least k such that for every distribution of k pebbles and every vertex r, a pebble can be moved to r. The optimal pebbling number ΠOPT (G) is the least k such that some distribution of k pebbles permits reaching eac...

In this work, sweeping gas membrane distillation (SGMD) process was used for concentrating of glucose syrup. The main questions in this work include: is SGMD process practical for concentrating of glucose solution prior the fermentation step in bioethanol process?. and are the commercially available hydrophobic membranes sufficient enough to develop the SGMD process in pilot scale for this issu...

Decisive heifer management for improved lactation and reduced dystocia requires a systematic analysis of age, body weight (BW), and average daily gain (ADG) using an adequately large sample size. The objective of this study was to determine effects of BW and age at first breeding and ADG until pregnancy on yields of milk, milk fat, and milk protein in the first lactation and the occurrence of d...