نتایج جستجو برای: fusion gene mrna
تعداد نتایج: 1311495 فیلتر نتایج به سال:
The human placenta has a remarkable capacity to aromatize C19-steroids, produced by the fetal adrenals, to estrogens. This reaction is catalyzed by aromatase P450 (P450arom), encoded by the CYP19 gene. In placenta, CYP19 gene expression is restricted to the syncytiotrophoblast layer. Cytotrophoblasts isolated from human placenta, when placed in monolayer culture in 20% O2, spontaneously fuse to...
Background: The aim of this research was to determine the Mn superoxide dismutase (Mn SOD) gene expression and the impact of oxidant and inflammatory markers on Mn SOD gene expression in active men and women. Methods: This research was a semi-experimental with repetitious measurement, and 24 active men (12) and women (12) (21-23 years) voluntarily participated in this research after ...
A large percentage of prostate cancers harbor TMPRSS2-ERG gene fusions, leading to aberrant overexpression of the transcription factor ERG. The target genes deregulated by this rearrangement, however, remain mostly unknown. To address this subject we performed genome-wide mRNA expression analysis on 6 non-malignant prostate samples and 24 prostate carcinomas with (n = 16) and without (n = 8) TM...
Avian metapneumovirus (aMPV) represents one of the most prevalent diseases of poultry mainly in combination with other pathogens, and it is increasing among chickens. In the present study, the detection and characterization of an aMPV subtype B strain circulating in broiler flocks based on fusion (F) gene. In phylogenetic analysis, the isolates are located in B subtype cl...
Abstract The mRNA epitranscriptome imparts diversity to gene expression by installing chemical modifications. Advances in detection methods have identified modifications eukaryotic, bacterial, and viral messenger RNAs (mRNAs). biological functions of mRNAs still remain be understood. Chemical are introduced synthetic meant for therapeutic applications maximize from the evade host immune respons...
Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...
Abstract: We describe an improved synthetic strategy for the preparation of nucleic acid encoded peptide and protein libraries. A solid-phase format was used to prepare and purify a novel type of mRNA-template for in vitro mRNA-protein fusion synthesis. The present protocol simplifies and accelerates the preparation of fusion libraries and should prove most useful for in vitro protein evolution...
Objective(s):Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. Materials andMethods:The human papillomavirus (HPV) type 18 E7 and eIF4E mRNAs were measured following knock down or overexpression of E7 gene by RT-P...
We analyzed the mRNA expression of the FHIT gene by reverse transcription-PCR (RT-PCR) in 54 cases of acute lymphoblastic leukemia (ALL; 11 cases of T-cell ALL [T-ALL] and 43 cases of non-T-ALL) and 40 cases of acute myeloid leukemia (AML). In 46% of the ALL cases and 55% of the AML cases, FHIT expression was absent or markedly decreased. Only abnormal short bands were detected in 30% of the AL...
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