نتایج جستجو برای: fulvestrant

تعداد نتایج: 782  

Journal: :The Journal of Sexual Medicine 2023

Abstract Introduction Vaginal dryness is a frequent complaint, especially in post-menopausal women. The physiology underlying the production of vaginal lubrication response to arousing stimuli established; however, no current pharmacological agents successfully target mechanisms utilizing this physiology. Previous research from our lab has demonstrated that female methamphetamine (meth) users e...

Journal: :Cancer discovery 2011
Brian A Van Tine Robert J Crowder Matthew J Ellis

Endocrine therapy-resistant estrogen receptor-positive (ER(+)) breast cancer is the most common cause of breast cancer death. Miller and colleagues demonstrate that ligand-independent ER activity promotes the growth of breast cancer cells through CDK4/E2F. As an independent event, the phosphatidylinositol 3-kinase (PI3K) pathway is also upregulated in endocrine therapy-resistant cells. Promisin...

2017
Denis Collins Wolfgang Jacob Juan Miguel Cejalvo Maurizio Ceppi Ian James Max Hasmann John Crown Andrés Cervantes Martin Weisser Birgit Bossenmaier

Bidirectional cross talk between members of the human epidermal growth factor family of receptors (HER) and the estrogen receptor (ER) is believed to underlie resistance mechanisms that develop in response to treatment with anti-HER agents and endocrine therapy. We investigated the interaction between HER2, HER3 and the ER in vitro using human embryonic kidney cells transfected with human HER2,...

2017
Lorna C. Gilligan Ali Gondal Vivien Tang Maryam T. Hussain Anastasia Arvaniti Anne-Marie Hewitt Paul A. Foster

Hormone replacement therapy (HRT) affects the incidence and potential progression of colorectal cancer (CRC). As HRT primarily consists of estrone sulfate (E1S), understanding whether this conjugated estrogen is transported and metabolized in CRC will define its potential effect in this malignancy. Here, we show that a panel of CRC cell lines (Colo205, Caco2, HCT116, HT-29) have steroid sulfata...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Ruth M O'Regan Clodia Osipo Eric Ariazi Eun Sook Lee Kathleen Meeke Caroline Morris Anne Bertucci Mohammad A B Sarker Ronald Grigg V Craig Jordan

PURPOSE Selective estrogen receptor modulators (SERM) are used for the treatment and prevention of breast cancer (tamoxifen) and osteoporosis (raloxifene). Mechanisms of tamoxifen-resistance in breast cancer are incompletely understood but current research is focused on crosstalk between growth factor receptors and the estrogen receptor alpha (ERalpha) pathway. There is increasing clinical use ...

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