Introduction The automation of cell culture processes becomes more important in the pharmaceutical industry due to compressed timelines and the need to develop more products more efficiently. This drive to develop new processes faster and more efficient requires a streamlined workflow. Resource intensive approaches like the use of shake flasks limit the accessible design space for the developme...

In previous chapters we analyzed data from so-called one-way experimental designs, in which subjects were randomly assigned to groups that di↵ered on a single treatment or grouping variable. In this chapter we will analyze data from factorial experiments. Factorial experiments contain two or more experimental variables. In a completely crossed factorial experiment, each level of every variable ...

In previous chapters we analyzed data from so-called one-way experimental designs, in which subjects were randomly assigned to groups that di↵ered on a single treatment or grouping variable. In this chapter we will analyze data from factorial experiments. Factorial experiments contain two or more experimental variables. In a completely crossed factorial experiment, each level of every variable ...

Titanium dioxide (TiO2) has various applications in consumer products and is also used as an additive in food and feeding stuffs. For the characterisation of this product, including the determination of nanoparticles, there is a strong need for the availability of corresponding methods of analysis. This paper presents an optimisation process for the characterisation of polydisperse-coated TiO2 ...

Experimental design method was used for HPLC determination of irbesartan and hydrochlorothiazide in combined dosage forms. The traditional approach for optimization of experiments is time-consuming, involves a large number of runs and does not allow establishing the multiple interacting parameters. The main advantages of the experimental design method include the simultaneous screening of a lar...

An experimental components analysis of brief HIV risk-reduction counseling based on the information-motivation-behavioral skills (IMB) model was conducted with 432 men and 193 women receiving sexually transmitted infection (STI) clinic services. Following baseline assessments, participants were randomly assigned to 1 of 4 90-min risk-reduction counseling sessions that deconstructed the IMB mode...