نتایج جستجو برای: fsgs
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BACKGROUND Focal and segmental glomerulosclerosis (FSGS) is the most common histologic pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10-30% of pediatric cases of steroid resistant nephrosis and/or FSGS. METHODS We studied the spectrum of genetic variation in 371 individuals with predomin...
BACKGROUND The putative circulating factor responsible for the glomerular permeability alterations induced in vitro by serum from patients affected by focal segmental glomerulosclerosis (FSGS) remains unidentified. We have observed that a serine proteinase isolated from patient serum increases albumin permeability in isolated glomeruli. The objective of the present study was to determine the ef...
Introduction Primary focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease. There are no US Food and Drug Administration-approved therapies for FSGS, and treatment often fails to reduce proteinuria. Endothelin is an important factor in the pathophysiology of podocyte disorders, including FSGS. Sparsentan is a first-in-class, orally active...
گلومرولواسکلروز فوکال و سگمنتال (FSGS)یکی از علل شایع سندرم نفروتیک در افراد بالغ و اطفال میباشد. این بیماری ممکن است بدون علت مشخص (اولیه یا ایدیوپاتیک) و یا ثانویه به آسیب قبلی گلومرولی (ثانویه) ایجاد گردد. در درمان این بیماری افتراق نوع اولیه از نوع ثانویه مهم است، چرا که درمان با تضعیفکنندههای سیستم ایمنی در بیشتر بیماران با نوع اولیه و نه نوع ثانویه اندیکاسیون دارد. بیماران مبتلا به F...
BACKGROUND Thy-1.1 transgenic mice develop hypercellular focal and segmental glomerulosclerosis (FSGS) lesions that mimic human collapsing FSGS, in 7 days after injection with anti-Thy-1.1 antibodies. These lesions consist of proliferating parietal epithelial cells (PECs). We questioned whether the angiotensin converting enzyme inhibitor (ACE), captopril, could prevent the development of FSGS a...
Focal segmental glomerulosclerosis (FSGS) and Alport syndrome (AS) are two major causes of end-stage renal disease (ESRD). A few families with autosomal dominant FSGS have been reported with linkage to chromosome 19q13 or 11q22, while AS is usually linked to mutations in type IV collagen (COL4) subunit genes. A phenotype resembling AS may also be seen with myosin heavy chain-9 (MYH9) gene mutat...
Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study.
Membranous nephropathy (MN) is considered the most common cause of nephrotic syndrome in white adults, but recent studies have shown an increasing incidence of focal segmental glomerulosclerosis (FSGS). These studies are difficult to interpret because the majority of cases came from urban tertiary referral centers. For validating these findings in the general population, trends in the incidence...
The numerical solutions of the second-order linear Fredholm integro-differential equations have been considered and discussed based on several discretization schemes. In this paper, new schemes are developed derived hybrid three-point half-sweep rational finite difference (3HSLRFD) approaches with composite trapezoidal (HSCT) approach. main advantage established is that they discretize differen...
Introduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and sparing other glomeruli, effacement the pedicels. The general objective was determine prevalence FSGS, give its profiles; epidemiological, clinical, biological, pathological, etiologi...
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