The quinoline ring system is one of the most ubiquitous heterocycles in the fields of medicinal and industrial chemistry, forming the scaffold for compounds of great significance. These include anti-inflammatory and antitumor agents, the antimalarial drugs quinine and chloroquine, and organic light-emitting diodes. Quinolines were first synthesized in 1879, and since then a multitude of synthet...

Abstract. This paper is companion to our earlier work [8] (see also announcement [7]). Let M be a closed manifold and Y be an embedded hypersurface, such that there is a decomposition of M = M1 ∪M2 into two manifolds with boundary M1 and M2 , with M1 ∩M2 = Y . In [8] we proved the decomposition formula for detζ∆ the ζ-determinant of a Dirac Laplacian ∆ on M . The contributions coming from M1 an...

The sequence of phosphoenolpyruvate carboxykinase (PEPCK) has been previously identified as a promising candidate for reconstructing Mesozoic-age divergences (Friedlander, Regier, and Mitter 1992, 1994). To test this hypothesis more rigorously, 597 nucleotides of aligned PEPCK coding sequence (approximately 30% of the coding region) were generated from 18 species representing Mesozoic-age linea...

Infantile hemangiomas (IHs) are the most common vascular tumors of childhood, affecting ∼5% of all infants. Although most lesions proliferate and then involute with minimal consequence, a significant minority can be disfiguring, functionally significant, or, rarely, lifethreatening. Recent discoveries concerning hemangioma pathogenesis provide both an improved understanding and more optimal app...

Blast waves generated in the field explosions impinge on the head-brain complex and induce mechanical pressure pulses in the brain resulting in traumatic brain injury. Severity of the brain injury (mild to moderate to severe) is dependent upon the magnitude and duration of the pressure pulse, which in turn depends on the intensity and duration of the oncoming blast wave. A fluid-filled cylinder...

This Special Issue is dedicated to the ALIO-INFORMS Joint International Meeting, held at the University of Buenos Aires, in Buenos Aires, Argentina, between the 6th and the 9th of June, 2010. This joint conference consisted of the INFORMS International Conference and XV CLAIO, the biannual conference organized by ALIO. The ALIO-INFORMS 2010 focused on topics such as services, logistics and tran...

There are several reasons why the study of the spectrum of the Laplacian in a narrow neighborhood of an embedded graph is interesting. The graph can be embedded into a Euclidean space or it can be embedded into a manifold. In his pioneering work [3], Colin de Verdière used Riemannian metrics concentrated in a small neighborhood of a graph to prove that for every manifold M of dimension greater ...

Blast has been the leading cause of injury, particularly traumatic brain injury and visual system injury, in combat operations in Iraq and Afghanistan. We determined the effect of shock tube-generated primary blast on retinal electrophysiology and on retinal and brain optic tract histopathology in a rat model. The amplitude of a- and b-waves on the electroretinogram (ERG) for both right and lef...

The methods of isolation and the immunological significance of specific carbohydrates from the three fixed types of Pneumococcus and of Friedlander’s bacillus have been described in a series of communications from this laboratory (1). These unusual polysaccharides, which are believed to be identical with the capsular material of the microorganisms from which they are derived, have been isolated...