Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even a...

The nut of Cola nitida Vent was extracted and examined for its starch constituent and physicochemical properties. The starch was isolated using 1%w/v sodium metabisulphite solution. The starch obtained had a fine texture, white, tasteless and odourless with a pH of 5.5 and moisture content of 9.67%. 75 mg acetylsalicylic acid tablet was formulated with novel starch using direct compression meth...

To demonstrate the potential alternative sources of starch used in tablet formulations, starches from taro (TS) and sweet potato (SPS) tubers were prepared with obtained yields of 11.0 and 9.6%, respectively. Both TS and SPS met USP22-NF17 identification and specifications. Their equilibrium moisture contents and gelatinization temperatures were comparable with those of commercial starch, where...

http://tag.sagepub.com 749 A 34-month-old boy of Caribbean/Hispanic descent, born abroad and raised in a Houston suburb, following 2 weeks in the Caribbean presented with new-onset painless gagging and vomiting multiple times per day. The emesis contained clear or partially digested food with an occasional bloody tinge. Physical examination and a barium swallow were unremarkable, and trials of ...

Objective: The objective of the present study was to formulate a controlled release floating tablet of Olmesartan Medoxomil. Methods: Floating tablets of Olmesartan Medoxomil were prepared by direct compression method using both natural (sodium alginate and carrageenan) and semi synthetic polymers (HPMC K4M, HPMC K100LV and HPMC E50LV).Sodium bicarbonate and calcium carbonate were used as gas g...

The type and the amount of binders decisively influence the characteristics of tablets prepared by wet granulation procedure. Commonly used binders like acacia, gelatin, starch and hydrolyzed starch have natural origin. The aim of this study was to evaluate the effectiveness of a new binder extracted from Hibiscus esculentus (Okra gum) in tableting. binder Hibiscus esculentus gum was extracted ...

The aim of the present research was to prepare and evaluate a gastroretentive drug delivery system for metformin HCl, using synthetic and semi-synthetic polymers. The floating approach was applied for preparing gastroretentive tablets (GRT) and these tablets were manufactured by the direct compression method. The drug delivery system comprises of synthetic and semi-synthetic polymers such as po...

Spherical crystallization is a novel particle engineering/design technique developed by Kawashima et al, to overcome the problems associated with direct compression. Basically, it's single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. The process of spherical crystallization involves simultaneous crystalliz...

An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For ...

Vitamins are widely used as a prescription medicine. The aim of the study is to prepare pyridoxine HCl tablets (200 mg) using direct compression technique which is now a days considered a cost effective and simple method of formulation. It can be considered as an appropriate method for hygroscopic and thermolabile substances. In the present study new formulations of Pyridoxine HCl was manufactu...