Since aging is the most important risk factor for variety of diseases, the discovery of a wide range of chemical modulators of aging in model organisms encourages new strategies for targeting age associated diseases. Simple genetic manipulation leads to long-lived and healthy animals, so any compound which could have similar effect would prove a boon to mankind. In the present study, effect of ...

In this paper, we fill a gap in the financial econometrics literature, by developing a “jump test” for the null hypothesis that the probability of a jump is zero. The test is based on realized third moments, and uses observations over an increasing time span. The test offers an alternative to standard finite time span tests, and is designed to detect jumps in the data generating process rather ...

We introduce a framework for modeling elastic properties of shape memory alloy polycrystals by coupling orientational degrees of freedom with elastic strains. Our method allows us to span the length scales from single crystal to that appropriate to obtain polycrystal properties. The single crystal free energy coefficients can be determined from microscopic calculations (such as electronic struc...

11 Allosteric molecules serve as regulators of cellular activity across all domains of life. We present a general 12 theory of allosteric transcriptional regulation that permits quantitative predictions for how physiological 13 responses are tuned to environmental stimuli. To test the model’s predictive power, we apply it to the 14 specific case of the ubiquitous simple repression motif in bact...

E vidence that calorie restriction (CR) retards aging and extends median and maximal life span was fi rst described in the 1930s by McCay et al. [1]. Since then, similar observations have been made in a variety of species including rodents, fi sh, fruit fl ies, worms, and yeast [2]—and although they are not yet defi nitive, results from ongoing longevity studies in monkeys suggest that CR will ...

  Background: Nano-biotechnology is considered as one of the mainly vigorous field of research in new material science. Recently, biosynthetic methods employing both biological microorganisms such as bacteria and fungus or plants extract have developed speedily as a trouble-free and feasible choice to obtain nanomaterials...

The surface adsorption of heavy metals in effluents with nanoparticles is today asuitable method for effluents treatment. In the present study, lignocellulose nano-fibers(LCNFs) were used as natural adsorbent for lead adsorption. The aim was to evaluate leadadsorption using adsorption isotherms, kinetics and thermodynamics. Fourier TransformInfrared Sp...