نتایج جستجو برای: free fetal dna

تعداد نتایج: 1076070  

Journal: :Clinical chemistry 2008
Y M Dennis Lo Rossa W K Chiu

BACKGROUND The discovery of circulating cell-free fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. The potential application of this technology for the noninvasive prenatal detection of fetal chromosomal aneuploidies is an aspect of this field that is being actively investigated. The main challenge of work in this area is the fact that c...

Journal: :Prenatal diagnosis 2008
Bernhard G Zimmermann Simon Grill Wolfgang Holzgreve Xiao Yan Zhong Laird G Jackson Sinuhe Hahn

Recent reports have indicated that digital PCR may be useful for the noninvasive detection of fetal aneuploidies by the analysis of cell-free DNA and RNA in maternal plasma or serum. In this review we provide an insight into the underlying technology and its previous application in the determination of the allelic frequencies of oncogenic alterations in cancer specimens. We also provide an indi...

2018
Elisabetta D’Aversa Giulia Breveglieri Patrizia Pellegatti Giovanni Guerra Roberto Gambari Monica Borgatti

Background: Fetal sex determination is useful for families at risk of X-linked disorders, such as Duchenne muscular dystrophy, adrenal hypoplasia, hemophilia. At first, this could be obtained through invasive procedures such as amniocentesis and chorionic villus sampling, having a 1% risk of miscarriage. Since the discovery of cell-free fetal DNA (cffDNA) in maternal plasma, noninvasive prenata...

Journal: :In vivo 2011
Georgia Tounta Christina Vrettou Aggeliki Kolialexi Nikolas Papantoniou Aspasia Destouni George T Tsangaris Aris Antsaklis Emmanuel Kanavakis Ariadni Mavrou

AIM To design a protocol for non-invasive prenatal diagnosis of fetal Rhesus D (RhD) status. MATERIALS AND METHODS A total of 112 single lymphocytes were used to test the efficiency of the assay. The protocol was validated using blood samples from 84 RhD-negative pregnant women at 7-24 weeks of gestation. Cell-free DNA (cfDNA) was enzymatically digested using AciI and analyzed by a polymerase...

Journal: :Journal of Turkish Society of Obstetric and Gynecology 2017

Journal: :PloS one 2016
Xu-Ping Xu Hai-Yan Gan Fen-Xia Li Qi Tian Jun Zhang Rong-Liang Liang Ming Li Xue-Xi Yang Ying-Song Wu

OBJECTIVE The fraction of circulating cell-free fetal (cff) DNA in maternal plasma is a critical parameter for aneuploidy screening with non-invasive prenatal testing, especially for those samples located in equivocal zones. We developed an approach to quantify cff DNA fractions directly with sequencing data, and increased cff DNAs by optimizing library construction procedure. METHODS Artific...

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