INTRODUCTION: G Protein-coupled Estrogen Receptor 1 (GPER1) is a novel receptor that binds to estrogen with high affinity. The receptor is present on growth plate chondrocytes, osteocytes, osteoblasts, and osteoclasts and has been shown to play a functional role in promoted growth plate closure and bone remodeling [1]. The finding from a mouse study with the deficiency of GPER1 protein showed a...

This work presents an effort to document and describe fracture surfaces for three commercially available amorphous polymers (PC, PMMA and ABS) each subjected to tension, impact and environmental stress cracking (ESC). We present mechanical properties as well as microscopic characterization at low and high magnification to distinguish between slow tensile loading, fast impact loading, and enviro...

Intergranular fracture in polycrystals is often simulated by finite elements coupled to a cohesive zone model for the interfaces, requiring cohesive laws for grain boundaries as a function of their geometry. We discuss three challenges in understanding intergranular fracture in polycrystals. First, 3D grain boundary geometries comprise a five-dimensional space. Second, the energy and peak stres...

The effects of temperature and loading rate on delamination growth were studied. The delamination fracture toughness of IM7/K3B was measured at 149°C, 177°C, and 204°C. At each temperature the tests were performed with a variety of loading rates so that the delamination initiated over the range of time from 0.5 sec to 24 hrs. The double cantilever beam (DCB) test was used to measure fracture to...

Geothermal resources offer a stable low-carbon energy source. However, geothermal sites can collocate with the hypocenters of large-magnitude seismic events. Large events pose risk to public safety and are therefore liability for efforts develop resources. Here, we propose “fracture caging” limit induced event magnitudes present evidence from numerical model predictions, laboratory experiments,...

The concentration and small size of nanodiamonds (NDs) plays a crucial role in the mechanical performance of epoxy-based nanocomposites by modifying the interface strength. Herein, we systemically analyzed the relation between the high concentration and small size of ND and the fracture properties of its epoxy-based nanocomposites. It was observed that there is a two-fold increase in fracture t...

Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real time because skeletal growth is slow and clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in infants and children. The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, th...

Two distinct mechanisms of crack initiation and advance by void growth have been identified in the literature on the mechanics of ductile fracture. One is the interaction a single void with the crack tip characterizing initiation and the subsequent void by void advance of the tip. This mechanism is represented by the early model of Rice and Johnson and the subsequent more detailed numerical com...

This paper presents a low cycle fatigue life curve by simulating a crack in a cover plate welded moment connection. Initiation of ductile fracture in steel is controlled by growth and coalescence of micro-voids. This research used a numerical method using finite element modeling and simulation of ductile crack initiation by a micromechanical model. Therefore, a finite element model of a cover p...

INTRODUCTION In children and adolescents distal forearm physeal fractures are common. Usually distal forearm physeal injuries of are common injuries in children and adolescents. Epiphyseal injuries to the distal radius are common in children, but involvement of the distal ulna is rare. Fracture of the distal radius with dislocation of the DRUJ is known as a True Galeazzi fracture dislocation an...