Curcumin is an inhibitor of p300 histone acetyltransferase activity, which is associated with the deterioration of heart failure. We reported that native curcumin, at a dosage of 50 mg/kg, prevented deterioration of the systolic function in rat models of heart failure. To achieve more efficient oral pharmacological therapy against heart failure by curcumin, we have developed a novel drug delive...

Dilated cardiomyopathy (DCM) is one of the most common types of cardiomyopathy worldwide. It is characterized by progressive chamber dilatation and myocardial systolic dysfunction and diagnosed by finding left ventricular (LV) enlargement and impaired systolic LV function (LV ejection fraction less than 50% or fractional shortening of less than 25-30%). Angiotensin-converting enzyme inhibitors ...

Echocardiographic measurements of the left ventricular dimensions and wall thicknesses at end diastole and end systole, aortic root and left atrial dimensions, mitral valve E-F slope, left ventricular ejection fraction, percent fractional shortening of the left ventricular internal dimension, estimated left ventricular mass and percentage systolic thickening of the ventricular septum and left v...

AIM To determine the correlation between insulin resistance and left ventricular systolic function in obese women. METHODS 44 obese (BMI > or =25 kg/m2) and 45 normal weight women were studied. They had no other pathological conditions. Echocardiograms were undertaken in our echocardiographic laboratory following standard methods. The homeostasis model was used to assess insulin resistance (H...

Apical four chamber view RV long axis dimensions Fractional shortening 31.6 + 7.7 26.8 + 7.5 < 0.05 FS (%) Systolic excursion of 23.7 + 3.3 20.9 + 2.9 < 0. 01 Tricuspid annulus (mm) Tricuspid Doppler flow velocities E wave/A wave velocity 1.20 + 0.32 1.12 + 0.40 > 0.05 Pressure half-time 52.3 + 10.2 46.2 + 11.2 < 0.05 (m.sec.) Doppler Pulmonary Flow velocity Peak velocity (cm/sec.) 94.3 + 16.8 ...

Hemochromatosis is a clinical syndrome caused by abnormal accumulation of iron in parenchymal organs leading to organ toxicity and dysfunction. Cardiac hemochromatosis is a cardiomyopathy due to primary iron-overload cardiomyopathy which causes congestive heart failure. Patients with cardiac hemochromatosis may be asymptomatic early in the disease. Once heart failure develops, there is rapid de...

the complex-step derivative approximation is applied to compute numerical derivatives. in this study, we propose a new formula of fractional complex-step method utilizing jumarie definition. based on this method, we illustrated an approximate analytic solution for the fractional cauchy-euler equations. application in image denoising is imposed by introducing a new fractional mask depending on s...

Echocardiography was used to study left ventricular size and contraction in 128 patients with isolated aortic valve disease 45 patients with aortic stenosis, 25 with mixed aortic valve disease and 58 with aortic regurgitation. Left ventricular measurements included the end-diastolic internal dimension (LVIDd), mural thickness (PWTd), an index of circumferential myocardial contraction fractional...

Transmitter-induced cyclostationarity has been explored recently as an alternative to fractional sampling and antenna array methods for blind identification of FIR communication channels. An interesting application of these ideas is in OFDM systems, which induce cyclostationarity due to the cyclic prefix. In this correspondence, we develop a novel subspace approach for blind channel identificat...