نتایج جستجو برای: fppi و ppi

تعداد نتایج: 766208  

2016
Clare Jinks Pam Carter Carol Rhodes Robert Taylor Roger Beech Krysia Dziedzic Steven Blackburn Rhian Hughes Bie Nio Ong

BACKGROUND The international literature on patient and public involvement (PPI) in research covers a wide range of issues, including active lay involvement throughout the research cycle; roles that patients/public can play; assessing impact of PPI and recommendations for good PPI practice. One area of investigation that is less developed is the sustainability and impact of PPI beyond involvemen...

Journal: :Neuroscience Letters 2012
Susan Satake Karen Yamada Liana Lins Melo Regina Barbosa Silva

Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. The inferior colliculus (IC) is a critical part of the auditory path...

2013
Bolin Chen Weiwei Fan Juan Liu

Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein^protein interaction (PPI) networks. We first describe issues an...

Journal: :Archives of general psychiatry 2006
Neal R Swerdlow Gregory A Light Kristin S Cadenhead Joyce Sprock Ming H Hsieh David L Braff

CONTEXT Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex. OBJECTIVE To assess the relationships between PPI deficits and demographic, clinical, neurocognitive, and functional status in a large cohort of patients with schizophrenia. DESIGN Cross-sectional comparison of patients with schizophrenia and...

2015
Ignasi Oliveras Cristóbal Río-Álamos Toni Cañete Gloria Blázquez Esther Martínez-Membrives Osvaldo Giorgi Maria G. Corda Adolf Tobeña Alberto Fernández-Teruel

Animal models of schizophrenia-relevant symptoms are increasingly important for progress in our understanding of the neurobiological basis of the disorder and for discovering novel and more specific treatments. Prepulse inhibition (PPI) and working memory, which are impaired in schizophrenic patients, are among the symptoms/processes modeled in those animal analogs. We have evaluated whether a ...

Journal: :The Journal of experimental biology 2010
Alfredo Oliveros Michael G Heckman Maria Del Pilar Corena-McLeod Katrina Williams Mona Boules Elliott Richelson

Pre-pulse inhibition (PPI) of the acoustic startle reflex is deficient in patients with schizophrenia. This deficiency is mimicked in mice by the use of the psychotomimetic drugs d-amphetamine and dizolcipine. Antipsychotic drugs such as clozapine are used to treat schizophrenic patients and are also administered to mice to prevent PPI disruption. Neurotensin (NT) produces antipsychotic-like ef...

Journal: :Korean journal of medical education 2010
Jae Jin Han Myoung Jin Lee Hyun-Jung Im

PURPOSE This research investigated the psychometric properties of the patient-physician interaction (PPI) domain in the clinical performance examination (CPX). This research aimed to understand the PPI domain in the CPX through a psychometric and relationship analysis between the domains. METHODS Data were drawn from 1,302 examinees on a set of 6 common CPX cases and 1,066 on a 'bad news deli...

Journal: :Clinical science and molecular medicine 1976
R G Russell S Bisaz H Fleisch

1. The urinary excretion of inorganic pyrophosphate (PPi), a known inhibitor of the growth and aggregation of crystals of calcium phosphate and calcium oxalate, increases after ingestion of orthophosphate (Pi). This effect may contribute to the apparent ability of oral phosphate to reduce the formation of urinary stones in man. This paper is a study of the mechanism by which Pi increases PPi ex...

Journal: :The Journal of clinical endocrinology and metabolism 2012
Hala H Mosli Alan Dennis Walter Kocha Linda J Asher Stan H M Van Uum

CONTEXT Chromogranin A (CgA) is used as a generic tumor marker for neuroendocrine tumors. Proton pump inhibitors (PPI) are known to increase CgA, but it is not clear to what extent, and there is little information on how long PPI need to be discontinued before the effect of PPI has disappeared. Furthermore, is it not known whether this PPI effect is dependent on the CgA assay used. OBJECTIVE ...

Journal: :Briefings in bioinformatics 2014
Mingyu Shao Yi Yang Jihong Guan Shuigeng Zhou

With the increase of available protein-protein interaction (PPI) data, more and more efforts have been put to PPI network modeling, and a number of models of PPI networks have been proposed. Roughly speaking, good models of PPI networks should be able to accurately describe PPI mechanisms, and thus reproduce the structures of PPI networks. With such models, theoretical and/or computational biol...

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  • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->