Lycium barbarum L. (LBL) has beneficial effects on gestational diabetes mellitus (GDM) but the related mechanism remains unclear. Polysaccharides of LBL (LBLP) are the main bioactive components of LBL. miR-33, ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding transcription 1 (SREBF1) affect lipid profiles, which are associated with GDM risk. LBLP may exert protec...

The present study represents the follow-up of our initial observations designed to investigate whether in patients with nonalcoholic steatohepatitis (NASH) the beneficial effect of 12-week course of melatonin (MT) on liver enzymes could be maintained with prolonged period of treatment and to analyze whether biochemical treatment responses could be sustainable after melatonin discontinuation. Fo...

PURPOSE We sought to investigate the safety and efficacy of gemcitabine, cisplatin, and lapatinib (GCL) as neoadjuvant therapy in patients with muscle-invasive bladder cancer (MIBC) planned for radical cystectomy. MATERIALS AND METHODS Four cycles of GCL were administered as neoadjuvant therapy for patients with MIBC. Although initially designed as a phase II efficacy study with a primary end...

The development of the seed-cones Taxus canadensis was studied. Aril is multilayered. seed coat multi-layered, its structure changes during development. Initially, it consists 33–35 layers cells, and by time maturation they are reduced to 10 layers. A marker sign appearance an aril from under scales. At this time, there active thickening cuticle epidermic cells seed, sclerenchymatization zone I...

A method is described whereby about 100 litres of plasma containing 10-50 IU/ml tetanus antitixin was obtained, from which were prepared 5000 X 250 IU doses of human antitetanus immunoglobulin. Of 40 blood donors who received a booster injection of tetanus vaccine BP, 33 were plasmapheresed each week over a 10-12 week period starting three weeks after the injection. Twenty-two of these donors p...

The Japanese quail has been utilized as a research species in establishing the genetic relationships that may also be present in other species. Divergent phenotypic selection for 4-wk BW was conducted for three generations in high (HW) and low (LW) lines. Within each line, 50 females and 25 males were selected among 600 birds, based on 4-wk BW. Mean BW at 4 wk of age in the base generation was ...

Background: 79% of the pregnant women suffer from sleep disorders. These disorders are the result of physiological, hormonal and physical changes. Sleep disorders before, during and after childbirth can affect the quality of life of pregnant women. This study aimed to evaluate the impact of behavioral health sleep education on the quality of life in the pregnant women with sleep disorder in the...