نتایج جستجو برای: founder effect
تعداد نتایج: 1647862 فیلتر نتایج به سال:
The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI) mouse strains derived from eight founder laboratory strains. RI panels are popular because of their long-term genetic stability, which enhances reproducibility and integration of data collected across time and conditions. Characterization of their genomes can be a community effort, reducing the burden on individual u...
Public corporations often appoint external former founders to their boards in hope that they will encourage a (re-)focus on creating future new business. Seeking investigate this common practice, we integrate upper echelons theory with imprinting theory, arguing founding company indeed represents formative experience leave an imprint and subsequent board decision-making. Subsequent experience, ...
Entrepreneurial ventures rely not only on founders, but also on “joiners” – startup employees who are attracted to entrepreneurship but do not want to be founders themselves. Drawing upon both individual and contextual-level perspectives of entrepreneurship, we examine how interests in being a founder or a joiner form prior to the first career transition. We find that individuals with founder a...
Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese males improves the metabolic health of female offspring, however whether this occurred in male offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n = 7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD-fed mice either remained sedentary (H...
Germline mutations in PMS2 are associated with Lynch syndrome (LS), the most common known cause of hereditary colorectal cancer. Mutation detection in PMS2 has been difficult due to the presence of several pseudogenes, but a custom-designed long-range PCR strategy now allows adequate mutation detection. Many mutations are unique. However, some mutations are observed repeatedly across individual...
Background Causative variants in BRCA1 and BRCA2 are well-established risk factors for breast and ovarian cancer. In Poland, the causative founder variants in the BRCA1 are responsible for a significant proportion of ovarian cancer cases, however, regional differences in the frequencies of various mutations may exist. The spectrum and frequency of BRCA1/2 mutations between ovarian cancer patien...
Alex Bennet and David Bennet 1 Co-Founder, Mountain Quest Institute, Frost, West Virginia; Chair Emeritus, U.S. Federal Knowledge Management Working Group; former Chief Knowledge Officer and Deputy Chief Information Officer for Enterprise Integration of the U.S. Department of the Navy. 2 Co-Founder, Mountain Quest Institute, Frost, West Virginia; former Chairman of the Board and CEO of a profes...
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