Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) has become increasingly important in clinical and forensic toxicology as well as doping control and is now a robust and reliable technique for routine analysis in these fields. In recent years, methods for LC-MS(/MS)-based systematic toxicological analysis using triple quadrupole or ion trap instrum...

Purpose In recent years, several publications have demonstrated the interest and usefulness of pharmacogenetics in forensic toxicology. However, this approach remains namely focused on DNA-based phenotype, which may potentially lead to misinterpretation. Other determinants such as co-medication or physiological parameters also impact phenotype. This article aims highlight importance considering...

For the analytical diagnosis of drug poisoning, it is important to develop conditions for detection both native compounds and products their biotransformation in biological samples. Aim. To a method isolating antidepressant Pyrazidol from human urine presence its determine that are suitable diagnostics thymoleptic intoxication by thin layer chromatography. Materials methods. The study was condu...

Historically, early identification and characterization of adverse effects of industrial chemicals was difficult because conventional toxicological test methods did not meet R&D needs for rapid, relatively inexpensive methods amenable to small amounts of test material. The pharmaceutical industry now front-loads toxicity testing, using in silico, in vitro, and less demanding animal tests at ear...

A new and simple procedure for the determination of parathion in human whole blood and urine using direct immersion (DI) solid-phase microextraction (SPME) and gas chromatography/mass spectrometry (GC/MS) is presented. This technique was developed using only 100 microL of sample, and ethion was used as internal standard (IS). A 65-microm Carbowax/divinylbenzene (CW/DVB) SPME fibre was selected ...

OBJECTIVE To determine the pattern of homicidal deaths caused by rifled weapons in Peshawar as regards the parameters of age, gender, place of occurrence and the number and location of injuries on the body. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The study was conducted at the Department of Forensic Medicine and Toxicology, Khyber Medical College, Peshawar, from June 200...

Aims To determine trends in 3,4 methylenedioxymethamphetamine (MDMA)-related death rates across Australia, Finland, Portugal and Turkey to analyse the toxicology causes of countries. Design Analysis MDMA-related deaths extracted from a national coronial database Australia (2001–19) forensic databases Finland (2001–17), (2008–19) (2007–17). Presentation MDMA use seizure data (market indicators)....

background and purpose: the internet offers a wide range of online digital resources for the field of toxicology. methods: the history of toxicology and electronic data collections are reviewed. this review presents a brief and non-comprehensive overview of a representative sampling of some of the broad array of toxicology-related learning, tutorial and information resources now becoming widely...