Two phase 2 studies of N-terminal tau–targeting antibody therapy fail to show clinical efficacy in progressive supranuclear palsy, despite evidence target engagement.

A family A ⊂ P[n] is said to be an antichain if A 6⊂ B for all distinct A,B ∈ A. A classic result of Sperner shows that such families satisfy |A| ≤ ( n bn/2c ) , which is easily seen to be best possible. One can view the antichain condition as a restriction on the intersection sizes between sets in different layers of P[n]. More generally one can ask, given a collection of intersection restrict...

Sexual harassment is perceived to be a major impediment to female labor force participation. Using novel data on all workplace sexual harassment precedent in US Circuit Courts from 1982-2002, we exploit the random assignment of US appellate judges and the fact that a judge’s gender and party of appointment predict decisions in sexual harassment cases to demonstrate the causal impact of pro-plai...

All models are wrong, but some are useful. 2 Acknowledgements The authors of this guide would like to thank David Warde-Farley, Guillaume Alain and Caglar Gulcehre for their valuable feedback. Special thanks to Ethan Schoonover, creator of the Solarized color scheme, 1 whose colors were used for the figures. Feedback Your feedback is welcomed! We did our best to be as precise, informative and u...

Max Weber claimed that while Protestantism provided the proper ethos necessary to spur capitalism, Eastern religions did not. Japan’s economic success has belied his hypothesis, and while there have been various theories explaining its rise, perhaps Weber’s own claims regarding the connection between embeddedness and capitalism best explain Japan’s rise. Simply put, Japanese capitalism was born...

The aim of this research is to produce an algorithm for the software that would let a researcher to observe the evolution of maximally parallel multiset-rewriting systems with permitting and forbidding contexts, browsing the configuration space by following transitions like following hyperlinks in the World-Wide Web. The relationships of maximally parallel multiset-rewriting systems with other ...

We report on the progress we have achieved in development of Emohawk, a 3D virtual reality application with an emergent narrative for teaching high-school students and undergraduates the basics of virtual characters control, emotion modelling, and narrative generation. Besides, we present a new methodology, used in Emohawk, for purposeful authoring of emergent narratives of Façade’s complexity....

Tractable classes of binary CSP and binary Max-CSP have recently been discovered by studying classes of instances defined by excluding subproblems. In this paper we characterise the complexity of all classes of binary Max-CSP instances defined by forbidding a single subproblem. In the resulting dichotomy, the only non-trivial tractable class defined by a forbidden subproblem corresponds to the ...