BACKGROUND Previous studies have demonstrated that pre-pubertal aryl hydrocarbon receptor knockout (AHRKO) mice have slow antral follicle growth and reduced capacity to produce estradiol compared to wild-type (WT) mice. Although previous studies have suggested that this is likely due to a reduced ability of the AHRKO follicles to respond to follicle-stimulating hormone (FSH), this possibility w...

Background: The aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment on ovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population. Materials and Methods: This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP wh...

The authors investigated immunoactive and bioactive follicle-stimulating hormone (FSH) secretion and clearance in six healthy young men during steady-state infusions of vehicle (basal, B, 28 hours), dihydrotestosterone (DHT, 4.5 days), or estradiol (4.5 days) accompanied by blood sampling at 10-minute intervals for 28 hours. Serum FSH concentrations were assayed by a two-site immunoradiometric ...

background: based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (fsh) and luteinizing hormone (lh) put on their main effects on the granulosa and theca cells. lh is essential for androgens production. androgens are used for estradiol production by granulosa cells. profound suppression of lh concentrations in some normogonadotropic patients can cau...

Polycystic Ovary Syndrome is a chronic endocrine disorder with clinical manifestations of oligomenorrhoea, amenorrhea, hirsuitism, ovarian dysfunction, and multiple cysts, affecting many women reproductive age. PCOS the primary cause ovulatory infertility worldwide. This study assessed concentration hormones in polycystic syndrome patients attending tertiary hospitals Niger Delta Region, Nigeri...

Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determ...

GonaCon is a single-shot immunocontraceptive vaccine that targets the reproductive hormone gonadotropin releasing hormone (GnRH). The GnRH peptide used in the vaccine is secreted by the hypothalamus of the brain and is specifically known as luteinizing hormone releasing hormone. This peptide stimulates the synthesis and secretion of luteinizing hormone and follicle stimulating hormone by the an...

Anovulation is a common cause of female subfertility. Treatment of anovulation is aimed at induction of ovulation. In women with clomiphene-citrate resistant WHO group II anovulation, one of the treatment options is ovulation induction with exogenous follicle-stimulating hormone (FSH or follitropin). FSH is derived from urine or is produced as recombinant FSH. Two forms of recombinant FSH are a...

Follicle stimulating hormone (FSH) is secreted from the pituitary gland to regulate reproduction in vertebrates. FSH signals through a G-protein coupled receptor (FSHR) on the target cell surface. We describe here the strategy to produce a soluble FSH-FSHR complex that involves the co-secretion of a truncated FSHR ectodomain (FSHR(HB)) and a covalently linked FSHalphabeta heterodimer from bacul...

Osteoporosis is increasingly found in the elderly and senile, maintaining its enormous medical social significance. The effect of hormones on bone metabolism beyond doubt. However, currently data sex tissue prevails. As for other hormones, sometimes, there are conflicting opinions. aim study: Based published data, to study contribution endocrine system development osteoporosis elderly. Material...