5,10-Methenyltetrahydrofolate synthetase (MTHFS) regulates the flow of carbon through the one-carbon metabolic network, which supplies essential components for the growth and proliferation of cells. Inhibition of MTHFS in human MCF-7 breast cancer cells has been shown to arrest the growth of cells. Absence of the three-dimensional structure of human MTHFS (hMTHFS) has hampered the rational desi...

Bee pollen is a rich bee product, from the point of view its nutritional and functional chemical characteristics. The composition properties make this product an excellent food supplement for human diet, due to various bioactivities, such as having antioxidant, antibacterial, antifungal, anti-inflammatory properties. These depend on botanical origin pollen. Castanea sativa one most important ty...

The aim of this study was twofold. first to examine the association anthropometric measures on kinematic characteristic which represent stroke efficiency in young female front crawl swimmers. second create a prediction model could provide help swimming coaches with purpose easier and better selection swimmers by measuring following basic morphological characteristics. Eighty competitive all mem...

OBJECTIVES The aim of this study was to evaluate latencies and corrected p13-n23 cervical vestibular evoked myogenic potentials (cVEMP) and n10-p13 ocular vestibular evoked myogenic potentials (oVEMP) amplitudes in patients with relapsing remitting multiple sclerosis (MS). METHODS This was a prospective, case-control study. Thirty patients with MS and 15 healthy controls were included. Cervic...

The relationship between central conduction time (CCT) and levels of regional blood flow were studied in 9 primates. Flows were recorded in both hemispheres using the method of hydrogen (2 min) clearance. The somatosensory evoked potentials were recorded over the contralateral cortex and the dorsal columns, following median nerve stimulation. The CCT, a measure of the brain's electrical conduct...

BACKGROUND Many surgeries are performed under spinal anesthesia. Inexperienced practitioners may find it difficult to obtain subarachnoid access. OBJECTIVES This study aimed to examine the relationship between patients' anthropometric characteristics and depth of spinal needle insertion to the subarachnoid cavity. PATIENTS AND METHODS 385 patients with ASA class I - II, aged 18 - 65 years a...

Temperature fluctuations significantly impact neurological injuries in intensive care units. As the benefits of therapeutic hypothermia continue to unfold, many of these discoveries are generated by studies in animal models undergoing experimental procedures under the influence of anesthetics. We studied the effect of induced hypothermia on neural electrophysiological signals of an uninjured br...

An apyrase (NTP/NDPase) implicated in the response of Mimosa pudica to stimuli, such as touch, has been cloned, sequenced and expressed in Escherichia coli. While purifying and characterizing this enzyme, it was observed that a chromophore is associated with it, having absorption in the ultraviolet-A/blue region of the spectrum. The absorbance maximum of the chromophore, purified from the enzym...