Welcome to this special issue of Journal Gastrointestinal and Abdominal Radiology (JGAR). Our concepts hepatic pathophysiology have advanced tremendously in the recent times, as for example, with understanding different types adenomas or role organic anion transporting polypeptides receptor hepatobiliary contrast uptake. Hepatic imaging techniques also made tremendous strides. In fact, a vast m...

It has been postulated that altered hepatic blood flow, particularly reduced portal flow, is responsible for the induction of hyperplasia of liver cells and nodule formation. This report describes the case of a 31-year old female patient developing multiple focal nodular hyperplasia (FNH) lesions two years after portocaval shunting and extended right hemihepatectomy due to the suspicion of a ma...

1. Richardson PG, Elias AD, Krishnan A, et al.Treatment of severe veno occlusive disease with defribotide: compassionate use results in efficacy without significant toxicity in high risk population. Blood 1997; 90(Suppl 1):252a. 2. Thung SN, Gerber MA, Bodenheimer HC Jr. Nodular regenerative hyperplasia of the liver in a patient with diabetes mellitus. Cancer 1982; 49:543-6. 3. Duvoux C, Kracht...

BACKGROUND Primary liver masses in children may require intervention because of symptoms or concern about malignant transformation. OBJECTIVES To review the management and outcome of benign liver masses in children. METHODS We conducted a retrospective chart review of children with liver masses referred to our institution during the period 1997-2009. RESULTS Benign liver masses were ident...

Two cases of spontaneous focal hepatic hyperplasia were observed in young female cynomolgus macaques (Macaca fascicularis). Grossly, a single raised nodule was observed in the left hepatic lobe. Histopathologically, the nodule compressed surrounding normal tissue; however, the hepatic cords within the nodule continued to those in the nor mal area except in part. Extensive fibrosis and absence o...

We found a high prevalence of RET expression among our papillary carcinoma at 77% 08 of 53); p< 0.001. Interestingly, the follicular adenomas and nodular hyperplasia cases exhibited a low expression of RET of 18% (9 of 50 cases) and 22.7% 05 of 66) respectively. RET/PTC re-arrangement has been demonstrated in these lesions before 7,8. It has been postulated that these positive follicular cell r...

A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive of focal nodular hyperplasia, while the remainder had the histological characteristics of a well-differentiated hepatocellular carcinoma. This is the first report of malignant transformation of a t...

The most common problems encountered in the differential diagnosis of hepatocellular lesions are: (a) adenoma vs well-differentiated hepatocellular carcinoma (HCC) in non-cirrhotic liver, (b) focal nodular hyperplasia (FNH) vs adenoma in non-cirrhotic liver, and (c) HCC vs high grade dysplastic nodules and other non-neoplastic nodules in cirrhotic liver. This discussion provides an update of im...

Introduction Benign hepatocellular tumors gather 2 separate groups of lesions according to their pathogenesis. Such classification has been successfully achieved owing to molecular studies, especially assessing their biological behaviour. Therefore, one distinguishes polyclonal disorders that concern regenerative non-neoplastic processes, such as focal nodular hyperplasia (FNH), and monoclonal ...