نتایج جستجو برای: fndc5

تعداد نتایج: 325  

2014
Yi-Hsin Tseng Yung-Hsin Yeh Wei-Jan Chen Kwang-Huei Lin

Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, th...

2015
Ghulam Nabi Naveed Ahmad Sardar Ali Sultan Ahmad

Irisin, a newly discovered myokine that reduces obesity and improve insulin resistance via the browning of white adipose tissues. Irisin is expressed and secreted in response to exercise, providing a hormonal link between exercise and improved insulin sensitivity. Several studies reported low irisin level in diabetic patient as compared to control. Therefore,it has been assumed that irisin may ...

2017
Junhao Huang Shen Wang Fengpeng Xu Dan Wang Honggang Yin Qinhao Lai Jingwen Liao Xiaohui Hou Min Hu

OBJECTIVE Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated ...

2013
Silja Raschke Jürgen Eckel

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only ...

2017
Zhijun Tan Zengchun Ye Jun Zhang Yanru Chen Cailian Cheng Cheng Wang Xun Liu Tanqi Lou Hui Peng

BACKGROUND Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis....

2017
ROBERT H. COKER ALYSSA N. WEAVER MELYNDA S. COKER CARL J. MURPHY HANNS-CHRISTIAN GUNGA MATHIAS STEINACH

PURPOSE The Yukon Arctic Ultra is considered the longest and coldest ultraendurance event in the world. Cold exposure and exercise has been reported to influence circulating levels of myokines, adipokines, and hepatokines that may influence considerable alterations in the regulation of metabolism. The purpose of the study was to evaluate the influence of the Yukon Arctic Ultra (430-mile event) ...

2014
Patricia R. Peter Kyung Hee Park Joo Young Huh Nicole M. Wedick Christos S. Mantzoros

UNLABELLED Irisin, secreted by skeletal muscle and possibly fat, is hypothesized to play an important role in modulating energy expenditure, obesity and metabolism. Coffee consumption also increases energy expenditure and leads to positive metabolic effects, but whether these effects are mediated by irisin remains unknown. The objective of this study was to determine the association between bas...

Journal: :European review for medical and pharmacological sciences 2016
X-Q Yang H Yuan J Li J-J Fan S-H Jia X-J Kou N Chen

OBJECTIVE Irisin, a newly discovered myokine, can drive the browning of white adipocytes to control body weight or mitigate obesity progression through regulating energy metabolism. However, the underlying mechanisms or specific signal pathways of exercise-induced irisin on the management of obesity are still unclear. MATERIALS AND METHODS Totally 30 rats were subjected to high fat diet (HFD)...

2016
Simon Oelmann Matthias Nauck Henry Völzke Martin Bahls Nele Friedrich

BACKGROUND/AIMS Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigatio...

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