Shear stress caused by blood flow is a potent physiological stimulus for the generation of nitric oxide (NO) in endothelial cells, which is believed to derive from the up-regulation and post-transcriptional activation of endothelial constitutive NO synthase (ecNOS). However, it has yet to be demonstrated that inducible NO synthase (iNOS) plays a significant role in shear stress-induced NO produ...

Vascular endothelial cells are directly and continuously exposed to fluid shear stress generated by blood flow. Shear stress regulates endothelial structure and function by controlling expression of mechanosensitive genes and production of vasoactive factors such as nitric oxide (NO). Though it is well known that shear stress stimulates NO production from endothelial nitric oxide synthase (eNOS...

We numerically investigate nonlinear regimes of shear-induced phase separation in entangled polymer solutions. Use is made of a time-dependent Ginzburg-Landau model describing two fluid dynamics of polymer and solvent. As a new dynamic variable a conformation tensor is introduced to represent chain deformations. Above the coexistence curve a dynamical steady states is attained, where fluctuatio...

This paper presents main results of a shale stability study, related to the understanding of shale/ fluid interaction mechanisms, and discusses shale strength correlation. The major shale/ fluid interaction mechanisms: Capillary, osmosis, hydraulic, swelling and pressure diffusion, and recent experimental results are discussed. Factors affecting the shale strength are discussed, and a sonic com...

Magnetorheological fluids consist of micron sized iron particles mixed in a carrier fluid, and are commonly used in adaptive dampers. Current simulations of MR fluids have been limited to thousands of particle and have been unable to simulate a a practical fluid volume (∼mm3) with a high solids loading (∼ 25 vol %). In this paper, we use NVIDIA’s CUDA programming environment to simulate over on...

Acoustic stimulation is a promising method for increasing drainage of non-Newtonian fluids through porous structures in various applications. In this study, a mathematical model is developed for unsteady flow of a bi-viscous incompressible fluid in a circular straight channel. Longitudinal vibrations are superimposed on the flow driven by changing pressure gradients along the channel. Simulatio...