Linear programming (LP) is a widely used optimization method for solving real-life problems because of its efficiency. Although precise data are fundamentally indispensable in conventional LP problems, the observed values of the data in real-life problems are often imprecise. Fuzzy sets theory has been extensively used to represent imprecise data in LP by formalizing the inaccuracies inherent i...

Site-specific exchange of genetic information is mediated by DNA recombinases, such as FLP or Cre, and has become a valuable tool in modern molecular biology. The so far low number of suitable recombinating enzymes has driven current research activities towards alteration of catalytic properties, such as thermostability or recognition sequences. However, identification and analysis of new mutan...

Frustrated Lewis pair (FLP) chemistry, a concept that has emerged in the last decade, presents unique systems capable of metal-free hydrogenation by using simple combinations of cooperative main group element components. This finding is particularly interesting given that hydrogenation is a chemical reaction that is performed on a huge scale worldwide with current technologies relying on metal-...

PURPOSE The aim of this study was to compare the efficacies of two-implant splinting (2-IS) and single-implant restoration (1-IR) in the first and second molar regions over a mean functional loading period (FLP) of 40 months, and to propose the appropriate clinical considerations for the splinting technique. MATERIALS AND METHODS The following clinical factors were examined in the 1-IR and 2-...

Over the years, the stable-model semantics has gained a position of the correct (two-valued) interpretation of default negation in programs. However, for programs with aggregates (constraints), the stable-model semantics, in its broadly accepted generalization stemming from the work by Pearce, Ferraris and Lifschitz, has a competitor: the semantics proposed by Faber, Leone and Pfeifer, which se...

Phytosensors are plants that are genetically engineered for sensing and reporting the presence of a specific contaminant, including agriculturally important biological agents. Phytosensors are constructed by transforming plants to contain specific biotic- or abiotic-inducible promoters fused to a reporter gene. When such transgenic plants encounter the target biotic or abiotic agent, the specif...

Monitoring of neuronal activity within circuits facilitates integrated responses and rapid changes in behavior. We have identified a system in Caenorhabditis elegans where neuropeptide expression is dependent on the ability of the BAG neurons to sense carbon dioxide. In C. elegans, CO2 sensing is predominantly coordinated by the BAG-expressed receptor-type guanylate cyclase GCY-9. GCY-9 binding...

The tad (tight adherence) locus of Aggregatibacter actinomycetemcomitans includes genes for the biogenesis of Flp pili, which are necessary for bacterial adhesion to surfaces, biofilm formation, and pathogenesis. Although studies have elucidated the functions of some of the Tad proteins, little is known about the regulation of the tad locus in A. actinomycetemcomitans. A promoter upstream of th...

The yeast Saccharomyces cerevisiae has proved to be an excellent model organism to study the function of proteins. One of the many advantages of yeast is the many genetic tools available to manipulate gene expression, but there are still limitations. To complement the many methods used to control gene expression in yeast, we have established a conditional gene deletion system by using the FLP/F...

Disparities between the predicted and the measured effective work functions (EWFs) in advanced metal oxide semiconductor devices, or Fermi-level pinning (FLP), have gained significant attention when high-k dielectrics began to emerge. Using a systematic approach for EWF extraction, combined with a comparison to unpinned SiO2 references, it was found that no intrinsic FLP exists in the model die...