Flexibility characteristics of biomacromolecules can be efficiently determined down to the atomic level by a graph-theoretical technique as implemented in the FIRST (Floppy Inclusion and Rigid Substructure Topology) and ProFlex software packages. The method has been successfully applied to a series of protein and nucleic acid structures. Here, we describe practical guidelines for setting up and...

In this paper, we discuss the use of fragmented bandwidth to improve the performance of staggered striping in a multimedia system. It is observed that potential disruptions can occur when nonconsecutive idle disks are used for displaying multimedia objects. We have identified useful retrieval patterns and shown that with proper selections of fragmented disks and a simple buffering scheme, disru...

Fixed dose combination (FDC) products are gaining more interest by pharma companies worldwide considering their importance in treating the disease and the increased safety/efficacy profile. Very few general guidelines are available with respect to FDCs in USA whereas Europe has some guidelines while India has just started developing such guidelines. Indian market is flooded with several irratio...